Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3359354
Reference Type
Journal Article
Title
microRNA-802/Rnd3 pathway imposes on carcinogenesis and metastasis of fine particulate matter exposure
Author(s)
Li, X; Lv, Y; Gao, N; Sun, H; Lu, R; Yang, H; Zhang, C; Meng, Q; Wu, S; Li, AQ; Xia, Y; Chen, R
Year
2016
Is Peer Reviewed?
1
Journal
Oncotarget
ISSN:
1949-2553
Volume
7
Issue
23
Page Numbers
35026-35043
Language
English
PMID
27144337
DOI
10.18632/oncotarget.9019
Web of Science Id
WOS:000377752100110
Abstract
Recent studies have linked ambient fine particulate matter (PM2.5) to increased lung cancer mortality and morbidity. However, the underlying mechanism causing the adverse effects of PM2.5 is less clear. In the present study, post-transcriptional profiling was used to explore biological pathways involved in PM2.5-induced pulmonary disorders. The carcinogenesis and metastasis of PM2.5 exposure were evaluated by long-term PM2.5 exposure tests. We observed dysregulation of actin in A549 cells line and dysplasia in the lungs of mice exposed to PM2.5. Both PM2.5-exposed cells and animals showed increased Rnd3 expression levels. Moreover, miR-802 mimics rescued actin disorganization in vitro and alveolitis in vivo. Long-term exposure to PM2.5 promoted carcinogenesis and metastasis of pulmonary cells. Decreased miR-802 expression levels in the serum samples of PM2.5-treated mice and individuals from moderately polluted cities were observed. Increased Rnd3 expression levels in lung cancers tissues have been identified by a genome database TCGA, and have been linked to less overall survival probabilities of lung cancer patients. Our findings suggest that dysregulation of actin cytoskeleton and down-regulation of miR-802 expression might be the underlying mechanism involved in the adverse effects of PM2.5 exposure. In addition, long-term exposure to PM2.5 demonstrated strong associations with malignant pulmonary disorders.
Keywords
PM2.5; microRNA; lung cancer; carcinogenesis; actin
Tags
NAAQS
•
ISA-PM (2019)
Considered
In Scope
Mode of action
PM Cancer-Genotox
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity