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3360146 
Journal Article 
A fast and sensitive method for the simultaneous analysis of a wide range of per- and polyfluoroalkyl substances in indoor dust using on-line solid phase extraction-ultrahigh performance liquid chromatography-time-of-flight-mass spectrometry 
Padilla-Sánchez, JA; Haug, LS 
2016 
Yes 
Journal of Chromatography A
ISSN: 0021-9673
EISSN: 1873-3778 
1445 
36-45 
English 
A fast and sensitive method for simultaneous determination of 18 traditional and 6 alternative per- and polyfluoroalkyl substances (PFASs) using solid-liquid extraction (SLE), off-line clean-up using activated carbon and on-line solid phase extraction-ultrahigh performance liquid chromatography-time-of-flight-mass spectrometry (on-line SPE-UHPLC-TOF-MS) was developed. The extraction efficiency was studied and recoveries in range the 58-114% were obtained. Extraction and injection volumes were also optimized to 2mL and 400μL, respectively. The method was validated by spiking dust from a vacuum cleaner bag that had been found to contain low levels of the PFASs in focus. Low method detection limits (MDLs) and method quantification limits (MQLs) in the range 0.008-0.846ngg(-1) and 0.027-2.820ngg(-1) were obtained, respectively. For most of the PFASs, the accuracies were between 70 and 125% in the range from 2 to100ngg(-1) dust. Intra-day and inter-day precisions were in general well below 30%. Analysis of a Standard Reference Material (SRM 2585) showed high accordance with results obtained by other laboratories. Finally, the method was applied to seven indoor dust samples, and PFAS concentrations in the range 0.02-132ngg(-1) were found. The highest median concentrations were observed for some of the alternative PFASs, such as 6:2-diPAP (25ngg(-1)), 8:2-diPAP (49ngg(-1)), and PFOPA (23ngg(-1)), illustrating the importance of inclusion of new PFASs in the analytical methods. 
Indoor dust; PFASs; PFOS; PFOA; PAPs; PFPAs; Analysis 
PFAS
• 6:2/8:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• 6:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• 8:2 diPAP
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• FtOH 8:2
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     FtOH 8:2 (678-39-7)
          Literature Search
               Pubmed
               WOS
     6:2 diPAP (57677-95-9)
          Literature Search
               Pubmed
               WOS
     8:2 diPAP (678-41-1)
          Literature Search
               Pubmed
               WOS
     6:2/8:2 diPAP (943913-15-3)
          Literature Search
               Pubmed
               WOS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS