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Citation
Tags
HERO ID
3452823
Reference Type
Journal Article
Title
Adrenomedullin regulates club cell recovery following lung epithelial injury
Author(s)
García-Sanmartín, J; Larrayoz, IM; Martínez, A
Year
2016
Is Peer Reviewed?
Yes
Journal
Histology and Histopathology
ISSN:
0213-3911
EISSN:
1699-5848
Volume
31
Issue
6
Page Numbers
663-673
Language
English
PMID
26661726
DOI
10.14670/HH-11-704
Web of Science Id
WOS:000376283700009
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964057247&doi=10.14670%2fHH-11-704&partnerID=40&md5=01f12726616d82c189a12db55eafd212
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Abstract
The equilibrium between lung epithelium damage and recovery in the context of chronic injury is at the basis of numerous lung diseases, including lung cancer and COPD. Understanding the contribution of growth factors and other molecular intermediates to this crosstalk may help in devising new therapeutic approaches. To better understand the contribution of adrenomedullin (AM) to lung homeostasis, we built club cell-specific conditional knockout (KO) mice for AM and subjected them to naphthalene injury. Untreated KO mice had lower levels of club cell 10 KDa protein (CC10) immunoreactivity than their wild type (WT) littermates in both terminal and regular bronchioles. Naphthalene injury resulted in a rapid necrosis of club cells followed by a progressive recovery of the epithelium. Club cells proliferated at higher rates in the KO mice and at 21 days post-injury the club cell coverage of the main bronchioles was higher and more homogeneous than in the WT animals. In conclusion, the paracrine/autocrine influence of AM in club cells subtly modulates their proliferation and spreading kinetics during lung epithelium recovery.
Tags
IRIS
•
Naphthalene
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Combined data set
Data set for title/abstract screening
Data set for full text review
Excluded – PECO criteria not met (full-text)
Supplemental material
Non-PECO routes of exposure
Other
•
Mouse Lung Tumor Workshop 2014
Mouse Lung Tumor Initial Search Sept-Oct 2023
PubMed
WoS
•
Naphthalene (2021 Evidence mapping publication)
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Combined data set
Data set for title/abstract screening
Data set for full text review
Excluded – PECO criteria not met (full-text)
Supplemental material
Exposure routes other than inhalation, oral, or dermal (animal studies)
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