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Citation
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HERO ID
3453058
Reference Type
Journal Article
Title
Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum
Author(s)
Yin, S; Tang, M; Chen, F; Li, T; Liu, W
Year
2017
Is Peer Reviewed?
Yes
Journal
Environmental Pollution
ISSN:
0269-7491
EISSN:
1873-6424
Publisher
ELSEVIER SCI LTD
Location
OXFORD
Volume
220
Issue
Pt B
Page Numbers
1429-1437
Language
English
PMID
27838061
DOI
10.1016/j.envpol.2016.10.090
Web of Science Id
WOS:000390732300073
URL
http://
://WOS:000390732300073
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Abstract
Polycyclic aromatic hydrocarbons (PAHs) are a type of ubiquitous pollutant with the potential ability to cause endocrine disruption that would have an adverse health impact on the general population. To assess the maternal exposure to PAHs in neonates and evaluate the possible impact of PAHs on reproductive hormone levels, the concentration of PAHs and reproductive hormone levels in the umbilical cord serum of 98 mother-infant pairs in the Shengsi Islands were investigated. The median concentration of total PAHs was determined to be 164 (Inter-Quartile Range, IQR 93.6-267) ng g(-1) lipid, and 68% of the PAHs were lower-molecule congeners. The highest level was found for pyrene (PYR) and naphthalene (NAP), which contributed 54.6% of all the PAHs present in the samples. The exposure to PAHs negatively affected estradiol (E2) and Anti-Mullerian hormones (AMH) and positively affected FSH in the umbilical cord serum. The result expanded the database of the human burden of PAHs and suggested that PAHs can act as a type of Endocrine-Disrupting Chemical (EDC). These results may help to understand the complex pathways involved in disorders of human reproductive health associated with prenatal exposure to PAHs.
Keywords
Polycyclic aromatic hydrocarbons (PAHs); Umbilical cord serum; Reproductive hormones; Environmental exposure
Tags
IRIS
•
Naphthalene
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Dermal/Multiple or Unknown Routes of Exposure
•
Naphthalene (2021 Evidence mapping publication)
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Dermal/Multiple or Unknown Routes of Exposure
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