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Citation
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HERO ID
3453087
Reference Type
Journal Article
Title
A novel synthetic cathinone, 2-(methylamino)-1-(naphthalen-2-yl) propan-1-one (BMAPN), produced rewarding effects and altered striatal dopamine-related gene expression in mice
Author(s)
Botanas, CJ; Yoon, SS; de La Peña, JB; Dela Peña, IJ; Kim, M; Woo, T; Seo, JW; Jang, CG; Park, KT; Lee, YH; Lee, YS; Kim, HJ; Cheong, JH
Year
2017
Is Peer Reviewed?
Yes
Journal
Behavioural Brain Research
ISSN:
0166-4328
EISSN:
1872-7549
Volume
317
Page Numbers
494-501
Language
English
PMID
27737791
DOI
10.1016/j.bbr.2016.10.016
Web of Science Id
WOS:000389086700054
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991710881&doi=10.1016%2fj.bbr.2016.10.016&partnerID=40&md5=3ab408102ece1d44a1dfe7ae44680b4d
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Abstract
The recreational use of synthetic cathinones has grown rapidly which prompted concerns from legal authorities and health care providers. However, in response to legislative regulations, synthesis of novel synthetic cathinones by introducing substituents in cathinone molecule has dramatically increased the diversity of these substances. Based on current trends, the aromatic ring is one of the popular sites in cathinone molecule being explored by designer-type modifications. In this study, we designed and synthesized a novel synthetic cathinone, 2-(methylamino)-1-(naphthalen-2-yl) propan-1-one (BMAPN), which has a naphthalene substituent on the aromatic ring. Thereafter, we determined whether BMAPN has rewarding and reinforcing effects through the conditioned place preference (CPP) test in mice and self-administration (SA) paradigm in rats. Locomotor sensitization was also assessed in mice during daily BMAPN treatment for 7days and drug challenge. Furthermore, we investigated the effects on BMAPN on dopamine-related genes in the striatum of mice using quantitative real-time polymerase chain reaction (qRT-PCR). BMAPN induced CPP at 10 and 30mg/kg and was modestly self-administered at 0.3mg/kg/infusion. Repeated BMAPN (30mg/kg) administration also produced locomotor sensitization. qRT-PCR analyses revealed decreased dopamine transporter and increased dopamine receptor D2 gene expression in the striatum of the BMAPN-treated mice. These data indicate that BMAPN has rewarding and reinforcing properties, which might be due to its effects on dopamine-related genes. The present study suggests that these findings may be useful in predicting abuse potential of future cathinone entities with aromatic ring substitutions.
Tags
IRIS
•
Naphthalene
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Excluded - PECO criteria not met (TIAB)
Other
•
Naphthalene (2021 Evidence mapping publication)
Database searches - Jan 2017 (private)
New Jan 2017 (private)
Database Searches
PubMed
WOS
Toxline
Combined data set
Data set for title/abstract screening
Excluded – PECO criteria not met
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