US EPA

3466600 

Journal Article 

Exposure to phthalates in children aged 5-7years: Associations with thyroid function and insulin-like growth factors 

Wu, W; Zhou, F; Wang, Y; Ning, Y; Yang, JY; Zhou, YK 

2017 

1 

Science of the Total Environment
ISSN: 0048-9697
EISSN: 1879-1026 

Elsevier B.V. 

579 

950-956 

English 

27884522 

10.1016/j.scitotenv.2016.06.146 

CCC:000391897800097 

https://search.proquest.com/docview/1877847211?accountid=171501
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This study aimed to evaluate the associations between phthalate concentrations and thyroid function in preschool children. We collected demographic data and biological samples from 216 children aged 5-7years. We calculated urinary concentrations of eight mono-phthalate metabolites (mPAEs) separately for children from urban and rural areas and investigated their associations with thyroid function and growth hormones. mPAE concentrations were higher in children from the urban area than in those from the rural area, and most mPAEs were positively associated with free triiodothyronine and free thyroxine. The insulin-like growth factor 1 (IGF-1) concentration decreased 0.082ng/mL (95% confidence interval [CI]: -1.34, -0.113) with each 1ng/mL increase in monomethyl phthalate (MMP) and 0.132ng/mL (95% CI: -0.209, -0.055) with each 1ng/mL increase in mono-n-butyl phthalate. The insulin-like growth factor binding protein 3 concentration decreased by 0.01mg/L (95% CI: -0.001, -0.000) or 0.01mg/L (95% CI: -0.003, -0.000) with each 1ng/mL increase in MMP or monoethyl phthalate, respectively. Exposure to some phthalates at 5-7years of age might interfere with thyroid hormones and growth. 

Toxicology Abstracts; Environment Abstracts; PAEs phthalate esters; mPAEs mono-phthalate metabolite; DMP dimethyl phthalate; DEP di-ethyl-phthalate; DBP di-n-butyl phthalate; DnOP di-n-octyl-phthalate; BBzP butyl benzyl phthalate; DEHP di(2-ethylhexyl)phthalate; MMP monomethyl phthalate; MEP monoethyl phthalate; MBP mono-n-butyl phthalate; MOP mono-isobutyl phthalate; MBzP monobenzyl phthalate; MEHP mono (2-ethylhexyl) phthalate; MEHHP 2-ethyl-5-hydroxy-hexyl-phthalate; MEOHP 2-ethyl-5-oxyhexyl phthalate; IGF-1 insulin-like growth factor 1; FT3 free triiodothyronine; TT3 total triiodothyronine; TT4 total thyroxine; FT4 free thyroxine; TSH thyroid stimulating hormone