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HERO ID
3469257
Reference Type
Journal Article
Subtype
Review
Title
A review of human biomonitoring data used in regulatory risk assessment under Canada's Chemicals Management Program
Author(s)
Zidek, A; Macey, K; Mackinnon, L; Patel, M; Poddalgoda, D; Zhang, Y
Year
2017
Is Peer Reviewed?
Yes
Journal
International Journal of Hygiene and Environmental Health
ISSN:
1438-4639
EISSN:
1618-131X
Publisher
Elsevier
Volume
220
Issue
2 Pt A
Page Numbers
167-178
Language
English
PMID
27816435
DOI
10.1016/j.ijheh.2016.10.007
Web of Science Id
WOS:000401215200021
URL
https://linkinghub.elsevier.com/retrieve/pii/S1438463916302012
Exit
Abstract
As a part of the Chemicals Management Plan launched in 2006, the Government of Canada is assessing and managing, where appropriate, the potential health and ecological risks associated with approximately 4300 substances under the Canadian Environmental Protection Act (1999). Since that time, nearly 3000 substances have been assessed, with human biomonitoring (HBM) data playing an increasingly important role for some substances. Case studies are presented, including both inorganic and organic substances (i.e., selenium, triclosan, phthalates), which highlight the impact and overall role HBM has had in regulatory decision making in Canada for these three substances as well as criteria used in the application of HBM data in human health risk assessment. An overview of its limitations in terms of how and when HBM data can be applied, when assessing human health in a regulatory setting, is discussed as well as the role HBM data can play in priority setting.
Keywords
Canada; Environmental Monitoring/methods; Environmental Pollutants/analysis/toxicity; Risk Assessment; Biomarkers; Butylbenzyl Phthalate (PubChem CID: 2347); Chemicals management plan; Dibutyl Phthalate (PubChem CID: 3026); Diisobutyl Phthalate (PubChem CID: 6782); Dimethyl Phthalate (PubChem CID: 8554); Disodecyl Phthalate (PubChem CID: 439488); Disononyl Phthalate (PubChem CID: 590836); Environmental chemicals; Exposure; Forward dosimetry; Human biomonitoring data; Reverse dosimetry; Selenium (PubChem CID: 6326970); Triclosan (PubChem CID: 5564)
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Literature Search
Literature Search: July 2016 - January 2017
PubMed
Literature Search: February 2017 - July 2017
Pubmed
Secondary Literature
Reviews/editorials
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jul 2016 - Jan 2017
Considered new
PubMed
LitSearch Jan 2017 - July 2017
Pubmed
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
July 2017 Update
PubMed
Secondary Literature
Reviews & editorials
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - Dec 2016 Update (Private)
Pubmed
Source - August 2017 Update (Private)
Pubmed
WOS
Source - August 2018 Update
Exclusions
Reviews
WOS
Toxline
Level 1 Screen - Title & Abstract
Excluded
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