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HERO ID
3469477
Reference Type
Journal Article
Title
Gestational exposure to phthalates and gender-related play behaviors in 8-year-old children: An observational study
Author(s)
Percy, Z; Xu, Y; Sucharew, H; Khoury, JC; Calafat, AM; Braun, JM; Lanphear, BP; Chen, A; Yolton, K
Year
2016
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Volume
15
Issue
1
Page Numbers
87
Language
English
PMID
27527835
DOI
10.1186/s12940-016-0171-7
Web of Science Id
WOS:000381568600001
Abstract
BACKGROUND:
Phthalates, used in a variety of consumer products, are a group of chemicals that are ubiquitous in the environment, and their metabolites are detectable in most humans. Some phthalates have anti-androgenic properties; a prior study reported an association between gestational exposure to phthalates and reduced masculine behaviors in preschool boys.
METHODS:
Concentrations of 9 phthalate metabolites were measured in urine collected at 16 and 26 weeks' gestation from pregnant women enrolled in the HOME Study, a prospective pregnancy and birth cohort. Measures of gender-related play were collected at 8 years of age, including the Gender Identity Questionnaire (GIQ) completed by mothers, and the Playmate and Play Style Preferences Structured Interview (PPPSI) completed by children. We examined these measures as continuous variables using both bivariate and multivariable approaches with adjustment for covariates. Additional analyses included logistic regression of GIQ and PPPSI scores dichotomized by sex at the lower 25th percentile, indicating the least typical behavior.
RESULTS:
Mothers' phthalate metabolite concentrations during pregnancy were similar to the reported national average among US women. All children scored within a typical range on both measures of gender-related play behavior. No statistically significant associations were found between averaged maternal phthalate metabolite concentrations and continuous PPPSI scores or any GIQ scores. For the dichotomized PPPSI; higher maternal monoethyl phthalate (MEP) concentrations were associated with more typical play behaviors for females (OR = 0.70, CI = 0.51-0.97). In contrast, higher maternal mono-isobutyl phthalate (MiBP) concentrations were associated with higher odds of membership in the least typical play behaviors group for males (OR = 1.69, CI = 1.00-2.86).
CONCLUSIONS:
In this sample of typically developing children, higher maternal urinary MEP concentrations during pregnancy were associated with more typical gender-related play behaviors in both males and females, and increased urinary MiBP concentrations were associated with less masculine gender-related play behaviors in males.
Keywords
Phthalates; Children; Play; Gender
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Additional Strategies
March 2017 Search strategy results
Studies with Health Effects Data
Human health effects studies
•
Diethyl phthalate (DEP)
Database searches
Jan 2020 update
PubMed
Web of Science
New for this project
Primary source of health effects
Human health effects studies
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
New for this search
Pubmed
Web of Science
Primary Source of Health Effects Studies
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DiBP
BBP
DEP
Source - Dec 2016 Update (Private)
Pubmed
WOS
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