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Tags
HERO ID
3479623
Reference Type
Journal Article
Title
Phthalate exposure, flavonoid consumption and breast cancer risk among Mexican women
Author(s)
Mérida-Ortega, Á; Hernández-Alcaraz, C; Hernández-Ramírez, RU; García-Martínez, A; Trejo-Valdivia, B; Salinas-Rodríguez, A; Svensson, K; Cebrián, ME; Franco-Marina, F; López-Carrillo, L
Year
2016
Is Peer Reviewed?
Yes
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Publisher
ELSEVIER IRELAND LTD
Location
CLARE
Volume
96
Page Numbers
167-172
Language
English
PMID
27690147
DOI
10.1016/j.envint.2016.08.023
Web of Science Id
WOS:000386933300018
URL
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988931949&doi=10.1016%2fj.envint.2016.08.023&partnerID=40&md5=b900c9cd221c15997207f884deb3237c
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Abstract
Objective: To evaluate if selected phthalate exposure and flavonoid intake interact on breast cancer (BC) risk.
Material and methods: Interviews and urine samples were obtained from 233 women with histologically confirmed BC and 221 healthy controls matched by age and place of residence, from various states of northern Mexico. Urinary metabolites concentrations of diethyl phthalate (DEP), butyl benzyl phthalate (BBzP) and dioctyl phthalate (DOP) were determined by solid-phase extraction coupled with high-performance liquid chromatography/isotope dilution/tandem mass spectrometry. Using a semiquantitative food frequency questionnaire, consumption of five types of flavonoids (anthocyanidins, flavan-3-ols, flavanones, flavones and flavonols) was estimated according to three food groups: vegetables, fruits and legumes-oil seeds.
Results: A higher intake of anthocyanidins and flavan-3-ols (from vegetables), synergistically increased the negative association between BBzP and BC. No other significant flavonoid-phthalate multiplicative interactions on the risk for BC were found.
Conclusion: The consumption of some flavonoids may interact with exposure to phthalates on the risk of BC. Epidemiological and underlying mechanisms information is still insufficient and requires further investigations.
Keywords
Phthalates; Flavonoids; Breast cancer risk
Conference Name
14th International Congress of Toxicology in conjunction with the 10th Mexican Congress of Toxicology
Conference Location
Merida, MEXICO
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Literature Search
Literature Search: July 2016 - January 2017
PubMed
WOS
Excluded: No Primary Data on Health Effects
Exposure levels
•
Diethyl phthalate (DEP)
Database searches
Jan 2017 update
Considered new
PubMed
Web of Science
Jan 2020 update
PubMed
Web of Science
New for this project
Primary source of health effects
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Other
Included
BBP
DEP
Source - Dec 2016 Update (Private)
Other
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