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Citation
Tags
HERO ID
3483277
Reference Type
Journal Article
Subtype
Supplemental Data
Title
Estimating uptake of phthalate ester metabolites into the human nail plate using pharmacokinetic modelling
Author(s)
Bui, TT; Alves, A; Palm-Cousins, A; Voorspoels, S; Covaci, A; Cousins, IT
Year
2017
Is Peer Reviewed?
Yes
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
100
Page Numbers
148–155
Language
English
PMID
28089278
DOI
10.1016/j.envint.2017.01.007
Web of Science Id
WOS:000394076900010
URL
https://search.proquest.com/docview/1861511098?accountid=171501
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Abstract
There is a lack of knowledge regarding uptake of phthalate esters (PEs) and other chemicals into the human nail plate and thus, clarity concerning the suitability of human nails as a valid alternative matrix for monitoring long-term exposure. In particular, the relative importance of internal uptake of phthalate metabolites (from e.g. blood) compared to external uptake pathways is unknown. This study provides first insights into the partitioning of phthalate-metabolites between blood and nail using pharmacokinetic (PK) modelling and biomonitoring data from a Norwegian cohort. A previously published PK model (Lorber PK model) was used in combination with measured urine data to predict serum concentrations of DEHP and DnBP/DiBP metabolites at steady state. Then, partitioning between blood and nail was assessed assuming equilibrium conditions and treating the nail plate as a tissue, assuming a fixed lipid and water content. Although calculated as a worst-case scenario at equilibrium, the predicted nail concentrations of metabolites were lower than the biomonitoring data by factors of 44 to 1300 depending on the metabolite. It is therefore concluded that internal uptake of phthalate metabolites from blood into nail is a negligible pathway and does not explain the observed nail concentrations. Instead, external uptake pathways are more likely to dominate, possibly through deposition of phthalates onto the skin/nail and subsequent metabolism. Modelling gaseous diffusive uptake of PEs from air to nail revealed that this pathway is unlikely to be important. Experimental quantification of internal and external uptake pathways of phthalates and their metabolites into the human nail plate is needed to verify these modelling results. However, based on this model, human nails are not a good indicator of internal human exposure for the phthalate esters studied.
Keywords
Human nail; Partitioning; Pharmacokinetic modelling; Phthalates
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
Pubmed
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
July 2017 Update
Web of Science
PubMed
Toxline
Additional Search Strategies
Supporting materials
Studies with Supporting Data
Toxicokinetics
No Primary Data on Toxic Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Toxnet
Excluded
Source - August 2017 Update (Private)
Pubmed
Toxnet
WOS
Source - August 2018 Update
WOS
Toxline
Level 1 Screen - Title & Abstract
Excluded
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