Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

3491307

Reference Type

Journal Article

Title

Towards preparative peroxygenase-catalyzed oxyfunctionalization reactions in organic media

Author(s)

Fernandez-Fueyo, E; Ni, Yan; Baraibar, AG; Alcalde, M; van Langen, LM; Hollmann, F

Year

2016

Is Peer Reviewed?

Yes

Journal

Journal of Molecular Catalysis B: Enzymatic
ISSN: 1381-1177

Publisher

Elsevier

Volume

134

Issue

Elsevier

Page Numbers

347-352

DOI

10.1016/j.molcatb.2016.09.013

Web of Science Id

WOS:000391074700012

URL

https://linkinghub.elsevier.com/retrieve/pii/S1381117716301771
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Abstract

The peroxygenase from Agrocybe aegerita (AaeUPO) has been evaluated for stereoselective oxyfunctionalization chemistry under non-aqueous reaction conditions.

The stereoselective hydroxylation of ethylbenzene to (R)-1-phenylethanol was performed in neat substrate as reaction medium together with the immobilized biocatalyst and (BuOOH)-Bu-tert as oxidant.

Stability and activity issues still have to be addressed. Nevertheless, gram-scale production of enan-tiopure (R)-1-phenylethanol was achieved with respectable 90,000 turnovers of the biocatalyst. (C) 2016 The Authors. Published by Elsevier B.V.

Keywords

Biocatalysis; Oxyfunctionalization; Hydroxylation; Non-aqueous reaction media; Peroxygenase