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Citation
Tags
HERO ID
3494370
Reference Type
Journal Article
Title
Simultaneous analysis of bisphenol A based compounds and other monomers leaching from resin-based dental materials by UHPLC-MS/MS
Author(s)
Putzeys, E; Cokic, SM; Chong, H; Smet, M; Vanoirbeek, J; Godderis, L; Van Meerbeek, B; Van Landuyt, KL; Duca, RC
Year
2017
Is Peer Reviewed?
Yes
Journal
Journal of Separation Science
ISSN:
1615-9306
EISSN:
1615-9314
Publisher
Wiley-VCH Verlag
Volume
40
Issue
5
Page Numbers
1063-1075
Language
English
PMID
28054450
DOI
10.1002/jssc.201601153
Web of Science Id
WOS:000397829700006
Abstract
Resin-based dental materials have raised debates concerning their safety and biocompatibility, resulting in a growing necessity of profound knowledge on the quantity of released compounds into the oral cavity. In this context, the aim of this study was to develop a comprehensive and reliable procedure based on liquid chromatography with mass spectrometry for the simultaneous analysis of various leached compounds (including bisphenol A based compounds) in samples from in vitro experiments. Different experiments were performed to determine the optimal analytical parameters, comprising mass spectrometry parameters, chromatographic separation conditions and sample preparation. Four internal standards were used: deuterated diethyl phthalate and bisphenol A (commercially available), and deuterated analogues of triethylene glycol dimethacrylate and urethane dimethacrylate (custom-made). The optimized method was validated for linearity of the calibration curves and the associated correlation coefficient, lower limit of quantification, higher limit of quantification, and intra- and inter-assay accuracy and precision. Additionally, the developed liquid chromatography with tandem mass spectrometry method was applied to the analysis of leaching compounds from four resin-based dental materials. The results indicated that this method is suitable for the analysis of different target compounds leaching from dental materials. This method might serve as a valuable basis for quick and accurate quantification of leached compounds from resin-based dental materials in biological samples. This article is protected by copyright. All rights reserved.
Keywords
dental materials; liquid chromatography; mass spectrometry; monomers; saliva
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
Pubmed
•
Diethyl phthalate (DEP)
Database searches
Jan 2017 update
Considered new
PubMed
Jul 2017 update
Web of Science
Jan 2020 update
PubMed
Web of Science
Excluded: No Primary Data on Health Effects
Use in sample prep or assay
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
Excluded
Source - August 2017 Update (Private)
WOS
Source - August 2018 Update
WOS
Level 1 Screen - Title & Abstract
Excluded
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