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3537045 
Journal Article 
Detection of butane metabolites as an indicator of butane abuse 
Kinoshita, H; Tanaka, N; Takakura, A; Kumihashi, M; Jamal, M; Ito, A; Kimura, S; Tsutsui, K; Nagasaki, Y; Matsubara, S; Ameno, K 
2016 
1 
Romanian Journal of Legal Medicine
ISSN: 1221-8618 
24 
3 
216-218 
WOS:000387428800013 
We have identified 2-butanol, 2-butanone, and t-butanol with
a faint peak of n-butane in a postmortem blood sample from an inhalant abuser by using head-space
solid-phase microextraction coupled with gas chromatography mass spectrometry (HS-SPME/GC-MS).
The compounds 2-butanol, 2-butanone, and t-butanol are metabolites of n-butane and isobutane. We
concluded that the victim had abused volatile gases prior to death. The identification of
metabolites of gases in the blood may be a good biomarker of volatile gas abuse. 
biomarker; abuse; volatile substance; head-space solid-phase microextraction with gas chromatography-mass spectrometry (HS-SPME/GC-MS) 
IRIS
• tert-Butanol
     Excluded/ Not on Topic
          Methodology/Solvent