US EPA

3540860 

Journal Article 

Identification and quantification by (1)H nuclear magnetic resonance spectroscopy of seven plasticizers in PVC medical devices 

Genay, S; Feutry, F; Masse, M; Barthélémy, C; Sautou, V; Odou, P; Décaudin, B; Azaroual, N; Armed Study Group 

2017 

Yes 

Analytical and Bioanalytical Chemistry
ISSN: 1618-2642
EISSN: 1618-2650 

SPRINGER HEIDELBERG 

HEIDELBERG 

409 

5 

1271-1280 

English 

27822646 

10.1007/s00216-016-0053-4 

WOS:000392622800010 

http://://CCC:000392622800010
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Medical devices are generally made of polyvinyl chloride plasticized by six authorized plasticizers as alternatives to di-(2-ethylhexyl)-phthalate (DEHP) classified as reprotoxic class 1b. These are acetyl tri-n-butyl citrate (ATBC), di-(2-ethylhexy) adipate (DEHA), di-(2-ethylhexyl) terephthalate (DEHT), di-isononyl cyclohexane-1,2-dicarboxylate (DINCH), di-isononyl phthalate (DINP), and tri-octyl trimellitate (TOTM). The main objective of this study was to propose a new method using (1)H NMR spectroscopy to determine and quantify these seven plasticizers in PVC sheets, standard infusion tubings, and commercially available medical devices. Two techniques were compared: dissolution in deuterated tetrahydrofuran and extraction by deuterated chloroform. Plasticizer (1)H NMR spectra were very similar in both deuterated solvents; dissolution and extraction provided similar results. The sensitivity of this method enabled us to detect and quantify the presence of minor plasticizers in PVC. In nine commercially available samples, the major plasticizer was identified and quantified by (1)H NMR. In six samples, one, two, or three minor plasticizers were identified and also quantified. DEHP was detected in only one tubing. NMR is therefore very convenient for studying plasticizers contained in medical devices. Only small quantities of solvents and sample are required. It is not necessary to dilute samples to enter a quantification range, and it is sufficiently sensitive to detect contaminants. 

nuclear magnetic resonance; plasticizers; polyvinyl chloride; medical devices; biomaterials; polymers