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HERO ID
3698497
Reference Type
Journal Article
Title
Anti-Inflammatory Activity of Selected Plants from Saudi Arabia
Author(s)
Abdallah, HM; Abdel-Naim, AB; Ashour, OM; Shehata, IA; Abdel-Sattar, EA
Year
2014
Is Peer Reviewed?
Yes
Journal
Zeitschrift fuer Naturforschung C
ISSN:
0939-5075
Volume
69
Issue
1-2
Page Numbers
1-9
Language
English
PMID
24772817
Web of Science Id
WOS:000336358000001
Abstract
Thirteen selected Saudi Arabian plants, belonging to seven different families, were tested for possible anti-inflammatory activity using the carrageenin-induced paw edema model in rats. The methanolic extracts of Vernonia schimperi, Trichodesma trichodesmoides var. tomentosum, and Anabasis articulate exhibited the highest anti-inflammatory activity. The active extracts were further subjected to fractionation with chloroform, ethyl acetate, and n-butanol and tested together with their mother liquor for their anti-inflammatory activity in the same rat model. The most potent fractions were the n-butanol fractions of Anabasis articulata and Vernonia shimperi and the aqueous mother liquor of Trichodesma trichodesmoides. Nevertheless, the three potent methanolic extracts showed higher anti-inflammatory activities than their individual fractions. The antioxidant properties were assessed by their in vitro 1,1-dipheny1-2-picryl-hydrazyl (DPPH) radical scavenging activities. It was concluded that the anti-inflammatory activity is dependent, at least in part, on the reduction of prostaglandin (PGE(2)) and tumour necrosis factor-alpha (TNF-alpha) levels and cyclooxygenase-2 (COX-2) activity.
Keywords
Anti-Inflammatory; Saudi Arabian Plants; COX
Tags
•
Chloroform 2018 Update
TITLE AND ABSTRACT REVIEW
Excluded Studies
•
Chloroform Combined (current)
Chloroform (original)
References: 2000-2018
WoS
Chloroform (2018 update)
TITLE AND ABSTRACT REVIEW
Excluded Studies
Chloroform (current)
Literature Search: Jan 2009 - March 2017
Web of Science
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