Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds
Marzouk, B; Mahjoub, M; Bouraoui, A; Fenina, N; Aouni, M; Marzouk, Z
| HERO ID | 3698812 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Anti-inflammatory and analgesic activities of a new cucurbitacin isolated from Citrullus colocynthis seeds |
| Authors | Marzouk, B; Mahjoub, M; Bouraoui, A; Fenina, N; Aouni, M; Marzouk, Z |
| Journal | Medicinal Chemistry Research |
| Volume | 22 |
| Issue | 8 |
| Page Numbers | 3984-3990 |
| Abstract | Current study was designed to explore the analgesic and the anti-inflammatory activities of a new cucurbitacin isolated from Tunisian Citrullus colocynthis Schrad. seeds. 11-Deoxocucurbitacin-I-2-O-beta-d-glucoside was isolated from C. colocynthis seed chloroform fraction. This organic fraction, one of its subfraction (F-19), and the purified 11-deoxocucurbitacin-I-2-O-beta-d-glucoside were investigated for anti-inflammatory activity using carrageenan-induced paw edema assay in rats at the doses of 0.5 and 1 mg/kg body wt for the chloroform fraction and of 0.1 and 0.5 mg/kg body wt for the F-19 subfraction and the purified product. For analgesic activity of different samples, the acetic acid and the phenylbenzoquinone writhing tests in mice were used at doses of 0.05, 0.1, and 0.5 mg/kg body wt. The results revealed that the seed chloroform fraction, the F-19 subfraction, and the 11-deoxocucurbitacin-I-2-O-beta-d-glucoside exerted significant in vivo anti-inflammatory and analgesic activities at all tested doses.These results suggest that 11-deoxocucurbitacin-I-2-O-beta-d-glucoside from C. colocynthis seeds possessed potential pharmacological values and could be further investigated for its design as a new lead compound for management of pain and inflammation. |
| Doi | 10.1007/s00044-012-0406-2 |
| Wosid | WOS:000320673200044 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Citrullus colocynthis Schrad.; Seeds; 11-Deoxocucurbitacin-I-2-O-beta-D-glucoside; Anti-inflammatory activity; Analgesic activity |