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Citation
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HERO ID
3749264
Reference Type
Journal Article
Title
Contribution of Direct and Indirect Exposure to Human Serum Concentrations of Perfluorooctanoic Acid in an Occupationally Exposed Group of Ski Waxers
Author(s)
Gomis, MI; Vestergren, R; Nilsson, H; Cousins, IT
Year
2016
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Volume
50
Issue
13
Page Numbers
7037-7046
Language
English
PMID
27304840
DOI
10.1021/acs.est.6b01477
Web of Science Id
WOS:000379366300053
Abstract
The contribution of direct (i.e., uptake of perfluorooctanoic acid (PFOA) itself) and indirect (i.e., uptake of 8:2 fluorotelomer alcohol (FTOH) and metabolism to PFOA) exposure to PFOA serum concentrations was investigated using a dynamic one-compartment pharmacokinetic (PK) model. The PK model was applied to six occupationally exposed ski waxers for whom direct and indirect exposures via inhalation were characterized using multiple measurements with personal air sampling devices. The model was able to predict the diverging individual temporal trends of PFOA in serum with correlation coefficients of 0.82-0.94. For the four technicians with high initial concentrations of PFOA in serum (250-1050 ng/mL), the ongoing occupational exposure (both direct and indirect) was of minor importance and net depuration of PFOA was observed throughout the ski season. An estimated average intrinsic elimination half-life of 2.4 years (1.8-3.1 years accounting for variation between technicians and model uncertainty) was derived for these technicians. The remaining two technicians, who had much lower initial serum concentrations (10-17 ng/mL), were strongly influenced by exposure during the ski season with indirect exposure contributing to 45% of PFOA serum concentrations. On the basis of these model simulations, an average metabolism yield of 0.003 (molar concentration basis; uncertainty range of 0.0006-0.01) was derived for transformation of 8:2 FTOH to PFOA. An uncertainty analysis was performed, and it was determined that the input parameters quantifying the intake of PFOA were mainly responsible for the uncertainty of the metabolism yield and the initial concentration of PFOA in serum was mainly contributing to the uncertainty of estimated serum half-lives.
Keywords
Transformation; Inhalation; Depuration; alcohols; perfluorooctanoic acid; Sampling; Pharmacokinetics; Occupational exposure; Metabolism; Models; Alcohol; Air sampling; Technicians; Simulation; Uptake
Tags
•
Additional PFAS (formerly XAgency)
•
FtOH 8:2
Literature Search
Pubmed
WOS
Screening Results
Toxicokinetic studies
PBPK models
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
Pubmed
WOS
FtOH 8:2 (678-39-7)
Literature Search
Pubmed
WOS
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
8:2 Fluorotelomer alcohol
Ammonium perfluorooctanoate
Perfluorinated compounds
Perfluorooctanoic acid
•
PFHxS
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
Pubmed
WOS
Screening Results
Susceptible populations
Literature Search Update (2013-2019)
PubMed
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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