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Citation
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HERO ID
3797585
Reference Type
Journal Article
Title
Dermal toxicity of ammonium perfluorooctanoate
Author(s)
Kennedy, GL
Year
1985
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Volume
81
Issue
2
Page Numbers
348-355
Language
English
PMID
4060160
DOI
10.1016/0041-008X(85)90172-3
Web of Science Id
WOS:A1985AUN2700019
Abstract
Ammonium perfluorooctanoate (CAS Registry No. 3825-26-2) is used commercially in the aqueous polymerization of fluorinated monomers. Because the chemical exists as a fine white powder which can come in contact with skin, its dermal toxicology was studied in rabbits and rats. Dermal applications of 0.5 g for 24 hr produced mild irritation to rabbit skin. The dermal LD50 was 4300 mg/kg for rabbits, 7000 mg/kg for male rats, and greater than 7500 mg/kg for female rats. Rat skin showed less irritation than rabbit skin and the general effects were more pronounced for the male (compared to the female) rat. Subchronic dermal treatment (10 applications, 5 doses, 2 rest days, 5 doses) with either 0, 20, 200, or 2000 mg/kg resulted in no, no, mild, or marked decreases in body weights, respectively. Increases in serum enzyme activities indicating hepatic effects occurred in treated rats. Liver weights were increased and necrosis and enlargement of hepatocytes were microscopically observed. Rats in the 2000-mg/kg-dose group also had epidermal necrosis at the application site. Blood organofluorine amounts were increased in a dose-related manner. All of the treatment-related toxicity findings resolved during a 42-day recovery period although prior exposure was evident by the presence of organofluorine in the blood.
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PFAS
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Additional PFAS (formerly XAgency)
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ATSDR
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Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
Potassium perfluorooctanoate
Sodium perfluorooctanoate
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PFAS 150
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Ammonium perfluorooctanoate
Perfluorooctanoic acid
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PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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R5-MI STSC Request
Other
•
Yale PFAS Liver study
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