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HERO ID
3840187
Reference Type
Journal Article
Title
Impact of community disadvantage and air pollution burden on geographic disparities of ovarian cancer survival in California
Author(s)
Vieira, VM; Villanueva, C; Chang, J; Ziogas, A; Bristow, RE
Year
2017
Is Peer Reviewed?
Yes
Journal
Environmental Research
ISSN:
0013-9351
EISSN:
1096-0953
Volume
156
Page Numbers
388-393
Language
English
PMID
28395243
DOI
10.1016/j.envres.2017.03.057
Web of Science Id
WOS:000403735300047
Abstract
Ovarian cancer survival varies geographically throughout California. The objective of this study is to determine the impact of living in disadvantaged communities on spatial patterns of survival disparities. Including a bivariate spatial smooth of geographic location within the Cox proportional hazard models is an effective approach for spatial analyses of cancer survival. Women diagnosed with advanced Stage IIIC/IV epithelial ovarian cancer (1996-2006) were identified from the California Cancer Registry. The impact of living in disadvantaged communities, as measured by the California Office of Environmental Health Hazard Assessment cumulative CalEnviroScreen 2.0 score, on geographic disparities in survival was assessed while controlling for age, tumor characteristics, quality of care, and race. Community-level air quality indicators and socioeconomic status (SES) were also independently examined in secondary analyses. The Cox proportional hazard spatial methods are available in the MapGAM package implemented in R. An increase in the community disadvantage from the 5th (less disadvantage) to the 95th percentile (more disadvantage) was significantly associated with poorer ovarian cancer survival (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.07-1.26). Ozone levels and SES were the most influential indicators on geographic disparities that warrant further investigation. The use of a bivariate smoother of location within the survival model allows for more advanced spatial analyses for exploring potential air quality-related predictors of geographic disparities.
Tags
NAAQS
•
ISA-Ozone (2020 Final Project Page)
Literature Search Results
Literature Search - Included
Keyword Search
Topic Classified Epidemiology
Topic Classified Exposure
Title-Abstract Screening (SWIFT-AS) - Included
Title-Abstract Screening (SWIFT-AS) - Included
Full-Text Screening Included
Full-Text Screening Included
Included in ISA First Draft
Appendix 6
Included in ISA Final Draft
Appendix 6
•
ISA-PM (2019)
In Scope
PM Cancer-Genotox
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