Health & Environmental Research Online (HERO)


Print Feedback Export to File
3857461 
Journal Article 
Human placental transfer of perfluoroalkyl acid precursors: Levels and profiles in paired maternal and cord serum 
Yang, L; Wang, Z; Shi, Y; Li, J; Wang, Y; Zhao, Y; Wu, Y; Cai, Z 
2016 
Yes 
Chemosphere
ISSN: 0045-6535
EISSN: 1879-1298 
Elsevier 
144 
Elsevier 
1631-1638 
English 
is supplemented by 3981678 : Supplementary materials
Perfluoroalkyl acids (PFAAs) precursors, the indirect source of PFAA exposure, have been observed in environmental and human samples. However, the maternal-fetal transfer of these chemicals has not been well examined. In this study, 50 paired maternal and cord serum samples collected in Jiangsu province of China were analyzed for fifteen PFAA precursors. Among the detected PFAAs, 6:2 fluorotelomer sulfonate (6:2 FTS), N-methyl- and N-ethyl-perfluorooctanesulfonamidoacetates had comparable detection rate in both maternal and cord sera, while the mean concentrations and detection rates of 8:2 FTS and perfluorooctane sulfonamide (PFOSA) were higher in maternal sera compared to cord sera (Mann-Whitney U test, P < 0.05). Analysis of variance and least significant difference tests showed that the youngest maternal age group (21-24 years old) had the highest concentration of 6:2 FTS in cord sera. Maternal serum PFOSA was found significantly correlated with the cord serum perfluorooctanesulfonate (PFOS) (Spearman test, r = 0.361, P = 0.010), indicating that maternal serum PFOSA might be an indirect source of PFOS in fetuses. The obtained results suggested the potential prenatal exposure and human placental transfer of perfluoroalkyl acid precursors. 
Perfluoroalkyl acids; Precursors; Placenta transfer; Prenatal exposure; Serum analysis 
PFAS
• FtS 6:2
     Literature Search
          Pubmed
          WOS
• FtS 8:2
     Literature Search
          Pubmed
          WOS
     Screening Results
          Toxicokinetic studies
               ADME
          Susceptible populations
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFOSA (754-91-6)
          Literature Search
               Pubmed
               WOS
     FtS 8:2 (39108-34-4)
          Literature Search
               Pubmed
               WOS
     FtS 6:2 (27619-97-2)
          Literature Search
               Pubmed
               WOS
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Toxicokinetic studies
               ADME
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFOSA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Susceptible populations