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Citation
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HERO ID
3857964
Reference Type
Journal Article
Title
The association between ambient fine particulate matter and incident adenocarcinoma subtype of lung cancer
Author(s)
Gharibvand, L; Lawrence Beeson, W; Shavlik, D; Knutsen, R; Ghamsary, M; Soret, S; Knutsen, SF
Year
2017
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Volume
16
Issue
1
Page Numbers
71
Language
English
PMID
28646928
DOI
10.1186/s12940-017-0268-7
Web of Science Id
WOS:000404157100001
Abstract
BACKGROUND:
Adenocarcinoma (AC) is the most common lung cancer among non-smokers, but few studies have assessed the effect of PM2.5 on AC among never smokers. The purpose of this study was to assess the association between ambient PM2.5 and incident lung AC in the Adventist Health and Smog Study-2 (AHSMOG-2), a cohort of 80,044 non-smokers (81% never smokers) followed for 7.5 years (597,177 person-years) (2002-2011).
METHODS:
Incident lung AC was identified through linkage with U.S. state cancer registries. Ambient PM2.5 levels at subjects' residences were estimated for the years 2000 and 2001, immediately prior to study start.
RESULTS:
A total of 164 incident lung AC occurred during follow-up. Each 10 μg/m(3) increment in PM2.5 was associated with an increase in the hazard rate of lung AC [HR = 1.31 (95% confidence interval (CI) 0.87-1.97)] in the single-pollutant model. Excluding those with prevalent non-melanoma skin cancer (NMSC) strengthened the association with lung AC (HR = 1.62 (95% CI, 1.11-2.36) for each 10 μg/m(3) PM2.5 increment. Also, limiting the analyses to subjects who spent more than 1 h/day outdoors, increased the estimate (HR = 1.55, 95% CI: 1.05, 2.30).
CONCLUSIONS:
Increased risk of AC was observed for each 10 μg/m(3) increment in ambient PM2.5 concentrations. The risk was higher among those without prevalent NMSC and those who spent more than 1 h/day outdoors.
Tags
NAAQS
•
ISA-Ozone (2020 Final Project Page)
Literature Search Results
Literature Search - Included
Keyword Search
Topic Classified Epidemiology
Title-Abstract Screening (SWIFT-AS) - Excluded
Manually Excluded
•
ISA-PM (2019)
In Scope
PM Cancer-Genotox
•
LitSearch-NOx (2024)
Forward Citation Search
Epidemiology
Results
Cancer
PubMed
WoS
Mortality-LT
PubMed
WoS
Keyword Search
Epidemiology
Mortality
WoS
Cancer
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Exposure
Confounding
WoS
Error Impacts
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PIA
WoS
•
Litsearch – PM ISA Supplement 2021
Pubmed iCite citation search (April 2021 BR)
PM2.5 Cardiovascular and Mortality Epi Search
Results
Merged search results (location and date exclusion applied)
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