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3858536 
Journal Article 
Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013 
Bjerregaard-Olesen, C; Bach, CC; Long, M; Ghisari, M; Bossi, R; Bech, BH; Nohr, EA; Henriksen, TB; Olsen, J; Bonefeld-Jørgensen, EC 
2016 
Yes 
Environment International
ISSN: 0160-4120
EISSN: 1873-6750 
91 
14-21 
English 
We aimed to estimate the levels and time trends of perfluorinated alkyl acids (PFAAs) in serum of 1533 Danish pregnant nulliparous women between 2008 and 2013. The selection criterion of only including nulliparous women was chosen to avoid confounding from parity. The serum samples were analyzed for sixteen PFAAs using solid phase extraction and liquid chromatography tandem mass spectrometry (LC-MS/MS). We investigated the time trends for seven PFAAs, which were detected in more than 50% of the samples: perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnA). We found that the serum levels of all seven PFAAs decreased during the period from 2008 to 2013; on average PFHxS decreased with 7.0% per year, PFHpS with 14.8%, PFOS with 9.3%, PFOA with 9.1%, PFNA with 6.2%, PFDA with 6.3%, and PFUnA with 7.1% per year. Adjustment for maternal age, body mass index (BMI), educational level and gestational age at blood sampling did not change the time trends much. To our knowledge, we are the first to report decreasing trends of PFNA, PFDA and PFUnA since year 2000, thereby indicating that the phase-out of these compounds are beginning to show an effect on human serum levels. 
Bio-monitoring; Pregnant women; Perfluorinated compounds; Serum concentrations; Temporal changes; Trends 
• ^Per- and Polyfluoroalkyl Substances (PFAS)
     PFOA (335-67-1) and PFOS (1763-23-1)
          Literature Search – Adverse outcome pathway (2015-present)
               Pubmed
               WOS
     PFUnA (2058-94-8)
          Literature Search
               Pubmed
               WOS
     PFDA (335-76-2)
          Literature Search
               Pubmed
               WOS
     PFNA (375-95-1)
          Literature Search
               Pubmed
               WOS
     PFHpS (375-92-8)
          Literature Search
               Pubmed
               WOS
     PFHxS (355-46-4)
          Literature search
               Pubmed
               WOS
• PFDA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Title and Abstract Screening
          Tagged as Supplemental
               Exposure assessment or qualitative exposure only
• PFHpS
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFHxS
     Literature Search
          PubMed
          WOS
     Screening Results
          Excluded/Not on Topic
• PFNA
     Literature Search
          Pubmed
          Toxline
          WOS
     Screening Results
          Excluded/Not on Topic
     PFNA Literature Search pre-2019
          WOS
          Pubmed
• PFOA (335-67-1) and PFOS (1763-23-1)
     Literature Search – Adverse outcome pathway (2015-present)
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic
     Literature Search Update (2013-2019)
          PubMed
          WOS
• PFUnA
     Literature Search
          Pubmed
          WOS
     Screening Results
          Excluded/Not on Topic