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Citation
Tags
HERO ID
3858667
Reference Type
Journal Article
Title
Isolating isomers of perfluorocarboxylates in polar bears (Ursus maritimus) from two geographical locations
Author(s)
De Silva, AO; Mabury, SA
Year
2004
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Publisher
AMER CHEMICAL SOC
Location
WASHINGTON
Volume
38
Issue
24
Page Numbers
6538-6545
Language
English
PMID
15669310
DOI
10.1021/es049296p
Web of Science Id
WOS:000225761800019
URL
https://search.proquest.com/docview/230128347?accountid=171501
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Abstract
The source of involatile, anthropogenic perfluorocarboxylate anions (PFCAs) in biota from remote regions is of heightened interest due to the persistence, toxicity, and bioaccumulation of these materials. Large-scale production of fluorinated compounds is carried out primarily by one of two methods: electrochemical fluorination (ECF) and telomerization. Products of the two processes may be distinguished based on constitutional isomer pattern as ECF products are characteristically comprised of a variety of constitutional isomers. The objective of this research was to develop a method for identifying the constitutional isomer profile of PFCAs in environmental samples and to apply the method to polar bear livers from two different locations. Resolution of constitutional isomers of derivatized PFCAs (8-13 carbons) was accomplished via GC-MS. Seven isomers of an authentic ECF perfluorooctanoate (PFOA) standard were separated. The linear isomer comprised 78% of this standard. Isomer profiles of PFCAs in liver samples of 15 polar bears (Ursus maritimus) from the Canadian Arctic and eastern Greenland were determined by GC-MS. The PFOA isomer pattern in Greenland polar bear samples showed a variety of branched isomers while only the linear PFOA isomer was determined in Canadian samples. Samples of both locations had primarily (>99%) linear isomers of perfluorononanoate and perfluorotridecanoate. Branched isomers of perfluorodecanoate, perfluoroundecanoate, and perfluorododecanoate were determined in the polar bear samples. Unlike the PFOA isomer signature, only a single branched isomer peak on the chromatograms was observed for these longer chain PFCAs. The presence of branched isomers suggests some contribution from ECF sources. However, in comparison to the amount of branched isomers in the ECF PFOA standard, such minor percentages of branched PFCAs may suggest additional input from an exclusively linear isomer source.
Keywords
Environmental Studies; Polar bears; Geography; Toxicity; Environmental science; Chemicals
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
Web of Science
Not prioritized for screening
Perfluorooctane
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFDoA (307-55-1)
Literature Search
Pubmed
WOS
PFUnA (2058-94-8)
Literature Search
Pubmed
WOS
PFDA (335-76-2)
Literature Search
Pubmed
WOS
PFNA (375-95-1)
Literature Search
Pubmed
WOS
•
PFAS 150
Literature Search Update December 2020
WOS
Literature Search August 2019
Web of Science
Not prioritized for screening
Perfluorooctane
•
PFBA
Protocol References
•
PFDA
Literature Search
Pubmed
WOS
Scopus: April 2021
Screening Results
Excluded/Not on Topic
Title and Abstract Screening
Excluded
Literature Searches (through April 2023 update and post-public comment/peer review)a
Title & Abstract Screening
Excluded
•
PFNA
Literature Search (August 2017)
Pubmed
PFNA Literature Search pre-2019
Pubmed
WOS
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
Title and Abstract Screening
Excluded
Not relevant to PECO
•
PFUnA
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
•
Yale PFAS Liver study
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