US EPA

3858726 

Journal Article 

Acute inhalation toxicity of ammonium perfluorononanoate 

Kinney, LA; Chromey, NC; Kennedy, GL 

1989 

Yes 

Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 

27 

7 

465-468 

English 

2777150 

10.1016/0278-6915(89)90033-1 

WOS:A1989AQ61100006 

https://search.proquest.com/docview/79199746?accountid=171501
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Ammonium perfluorononanoate (CAS Registry No. 4149-60-4) is a white powder that can become airborne. Its acute inhalation toxicity in male rats was studied. Male rats were exposed for single 4-hr periods to dust concentrations ranging from 67 to 4600 mg/m3. The LC50 was determined to be 820 mg/m3, with the lowest concentration causing death being 590 mg/m3. Ammonium perfluorononanoate was classified as moderately toxic by the acute inhalation route. Exposure to ammonium perfluorononanoate caused a pronounced increase in liver size. The acute toxicity of ammonium perfluorononanoate appears to be similar to that of its 8-carbon homologue, ammonium perfluorooctanoate, but considerably less than that of the 10-carbon homologue, perfluoro-n-decanoic acid. 

Air Pollutants; Caprylates; Fluorocarbons; hexadecafluoro-nonanoic acid; 76-21-1; perfluorooctanoic acid; 947VD76D3L; Index Medicus; Animals; Body Weight -- drug effects; Liver -- drug effects; Administration, Inhalation; Organ Size -- drug effects; Liver -- pathology; Caprylates -- toxicity; Fluorocarbons -- toxicity; Air Pollutants -- toxicity