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Citation
Tags
HERO ID
3858752
Reference Type
Journal Article
Title
Peroxisomal enzymes and 8-hydroxydeoxyguanosine in rat liver treated with perfluorooctanoic acid
Author(s)
Abdellatif, A; Al-Tonsy, AH; Awad, ME; Roberfroid, M; Khan, MN
Year
2003
Is Peer Reviewed?
Yes
Journal
Disease Markers
ISSN:
0278-0240
Publisher
HINDAWI LTD
Location
LONDON
Volume
19
Issue
1
Page Numbers
19-25
Language
English
PMID
14757943
DOI
10.1155/2003/135859
Web of Science Id
WOS:000221266200003
Abstract
Although peroxisome proliferators are considered non-genotoxic agents, most of them, nevertheless, were found to promote and/or induce, hepatocellular carcinoma (HCC) in rodents. The aim of the present study is, first, to investigate whether the peroxisome proliferator perfluorooctanoic acid (PFOA) possesses inherent liver cancer promoting activity, and second, to study the possible mechanisms involved. To acheive these aims two protocols have been applied, a biphasic protocol (initiation by diethyl-nitrozamine (DEN) 200 mg/kg i.p. followed by treatment with 0.005% or 0.02% perflourooctanoic acid (PFOA) for 14 and 25 weeks) and a triphasic initiation, selection-promotion (IS) protocol (initiation by giving 200 mg/kg DEN i.p. followed by a selection procedure for 2 weeks consisting of giving 0.03% 2-acetylaminofluorene (2-AAF) in diet). In the middle of this treatment a single oral dose of carbon tetrachloride (2.0 ml/kg) was given, followed by giving diet containg 0.015% of PFOA for 25 weeks. After applying both protocols, our results showed slight increase in the catalase activity while acyl CoA oxidase activity was markedly increased. Both experiments indicated that PFOA has a liver cancer promoting activity. Other groups of rats were given either basal diet or diet containing 0.02% PFOA. Five or nine weeks later they were sacrificed and the levels of 8-hydroxydeoxyguanosine in the isolated DNA were estimated. The data showed a slight nonetheless insignificant increase in 8-hydroxydeoxyguanosine. From the present data, it is concluded that PFOA is a true liver cancer promoter that may not require extensive initial DNA damage for its promoting activity.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
ATSDR
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Not prioritized for screening
Potassium perfluorooctanoate
Sodium perfluorooctanoate
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFDA (335-76-2)
Literature Search
WOS
•
PFAS 150
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Ammonium perfluorooctanoate
Perfluorodecanoic acid
Perfluorooctanoic acid
•
PFBA
Protocol References
•
PFDA
Literature Search
WOS
Screening Results
Excluded/Not on Topic
Title and Abstract Screening
Excluded
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