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HERO ID
3859025
Reference Type
Journal Article
Title
Estimated daily intake and cumulative risk assessment of phthalates in the general Taiwanese after the 2011 DEHP food scandal
Author(s)
Chang, JW; Lee, CC; Pan, WH; Chou, WC; Huang, HB; Chiang, HC; Huang, PC
Year
2017
Is Peer Reviewed?
1
Journal
Scientific Reports
EISSN:
2045-2322
Publisher
Nature Publishing Group
Location
LONDON
Book Title
Sci Rep. 2017, 03 22; 7:45009. [Scientific reports]
Volume
7
Page Numbers
45009
Language
English
PMID
28327585
DOI
10.1038/srep45009
Web of Science Id
WOS:000396984800001
URL
http://
://WOS:000396984800001
Exit
Abstract
A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan's general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach. The creatinine-based model showed that the highest DI values in children 7-to 12- years-old were for DEHP (males: median: 4.79 μg/kg bw/d; females: median: 2.62 μg/kg bw/d). The 95(th) percentile (P95) of HQrep values were all >1 in the 7- to 12-year-old and 18- to 40-year-old male groups. The P95 of HQhep values were all >1 in the 7- to 18- year-old male groups. Most of the HQrep was attributable to the HQs of DnBP and DiBP (53.9-84.7%), and DEHP contributed most to HQhep (83.1-98.6%), which reveals that DnBP, DiBP and DEHP were the main risk of phthalate exposure for Taiwanese. Taiwan's general population is widely exposed to DnBP, DiBP and DEHP, especially for young children.
Keywords
Adolescent; Aged, 80 and over; Environmental Exposure/adverse effects; Food Contamination; Food Safety; Middle Aged; Phthalic Acids/adverse effects; Public Health Surveillance; Risk Assessment; Toxicity Tests; Urinalysis; Young Adult; 6O7F7IX66E
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
Pubmed
WOS
LitSearch July 2017 - Sept 2018
Prior Search Overlap
WOS
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
July 2017 Update
Web of Science
PubMed
Toxline
New for this search
Secondary Literature
Risk assessments
No Primary Data on Toxic Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Toxnet
Excluded
Source - August 2017 Update (Private)
Pubmed
Toxnet
WOS
Source - August 2018 Update
WOS
Toxline
Level 1 Screen - Title & Abstract
Excluded
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