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Citation
Tags
HERO ID
3859029
Reference Type
Journal Article
Title
Novel bioactive molecules from Lentzea violacea strain AS 08 using one strain-many compounds (OSMAC) approach
Author(s)
Hussain, A; Rather, MA; Dar, MS; Aga, MA; Ahmad, N; Manzoor, A; Qayum, A; Shah, A; Mushtaq, S; Ahmad, Z; Hassan, QP
Year
2017
Is Peer Reviewed?
Yes
Journal
Bioorganic & Medicinal Chemistry Letters
ISSN:
0960-894X
EISSN:
1464-3405
Volume
27
Issue
11
Page Numbers
2579-2582
Language
English
PMID
28400238
DOI
10.1016/j.bmcl.2017.03.075
Web of Science Id
WOS:000402023800059
Abstract
A new eudesmane sesquiterpenoid (1), and a new homologue of virginiae butanolide E (2) along with butyl isobutyl phthalate (3) were isolated from, actinomycete-Lentzea violacea strain AS08 isolated from north western Himalayas by stressing on modified one strain-many compounds (OSMAC) method. The structures of the new compounds were elucidated by extensive spectroscopic analyses including 1D, 2D NMR along with HR-ESI-MS and FT-IR data. Herein, a distinctive method was added for inspecting secretory profile of the strain by quantification of extract value of cell free supernatant in different types of culture media fallowed by HPLC profiling of respective extracts, which revealed a highly altered metabolic profile of the strain and formed the base for the selection of media. The compounds 1 and 2 showed moderate activity against Gram negative (MIC ∼32-64µgml(-1)) in comparison to Gram positive bacterial pathogens. Compound 1 exhibited significant activity in human cancerous cell lines (IC50 ∼19.2µM).
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
LitSearch Jan 2017 - July 2017
Pubmed
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
January 2017 Update
July 2017 Update
Web of Science
PubMed
New for this search
No Primary Data on Toxic Effects
Not chemical specific
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - August 2017 Update (Private)
Pubmed
WOS
Source - August 2018 Update
WOS
Toxline
Level 1 Screen - Title & Abstract
Excluded
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