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HERO ID
3859496
Reference Type
Journal Article
Title
Prevention of neutrophil-mediated injury to endothelial cells by perfluorochemical
Author(s)
Babbit, DG; Forman, MB; Jones, R; Bajaj, AK; Hoover, RL
Year
1990
Is Peer Reviewed?
1
Journal
American Journal of Pathology
ISSN:
0002-9440
EISSN:
1525-2191
Report Number
BIOSIS/90/12432
Volume
136
Issue
2
Page Numbers
451-460
Language
English
Web of Science Id
WOS:A1990CP70300021
Abstract
BIOSIS COPYRIGHT: BIOL ABS. Myocardial salvage after reperfusion may be limited by neutrophil-mediated microvascular damage. The effect of the perfluorochemical, Fluosol-DA, and its various components on neutrophil adherence, cytotoxicity, and proteolytic enzyme release was examined on sheep large and small vessel endothelial cells in vitro. Cells were studied under normoxic (N) and anoxic conditions (A). Various concentrations of Fluosol (10%, 25%, and 50%) significantly reduced neutrophil adherence under both experimental conditions (mean 22 | 3.25% versus 7 | 0.8% (N) and 20 | 3.2% versus 7.5 | 0.9% (A); P and lt; 0.01). The perfluorocarbons, perfluorodecalin (PFD), and perfluoro-tripropylamine (PFTP) in a 50 volume/percent concentration exhibited profound effects on adherence, particularly on cells subjected to anoxia (51% and 69% reduction in adherence, respectively; P and lt; 0.01). No effect on adherence was observed with other components including the detergent, pluroinc F68. A 25% reduction (P and
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PFAS
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFDS (335-77-3)
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