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Citation
Tags
HERO ID
3860366
Reference Type
Journal Article
Title
Covalent immobilization of antibacterial furanones via photochemical activation of perfluorophenylazide
Author(s)
Al-Bataineh, SA; Luginbuehl, R; Textor, M; Yan, M
Year
2009
Is Peer Reviewed?
1
Journal
Langmuir
ISSN:
0743-7463
EISSN:
1520-5827
Volume
25
Issue
13
Page Numbers
7432-7437
Language
English
PMID
19563228
DOI
10.1021/la900334w
Web of Science Id
WOS:000267533800043
Abstract
N-(3-trimethoxysilylpropyl)-4-azido-2,3,5,6-tetrafluorobenzamide (PFPA-silane) was used as a photoactive cross-linker to immobilize antibacterial furanone molecules on silicon oxide surfaces. This immobilization strategy is useful, especially for substrates and molecules that lack reactive functional groups. To this end, cleaned wafers were initially incubated in solutions of different concentrations of PFPA-silane to form a monolayer presenting azido groups on the surface. The functionalized surfaces were then treated with a furanone solution followed by illumination with UV light and extensive rinsing with ethanol to remove noncovalently adhered molecules. In the presented study, we demonstrate the ability to control the surface density of the immobilized furanone molecules by adjusting the concentration of PFPA-silane solution used for surface functionalization using complementary surface analytical techniques. The fluorine in PFPA-silane and the bromine in furanone molecules were convenient markers for the XPS study. The ellipsometric layer thickness of the immobilized furanone molecules on the surface decreased with decreasing PFPA-silane concentration, which correlated with a decline of water contact angle as a sign of film collapse. The intensity of characteristic azide vibration in the MTR IR spectra was monitored as a function of PFPA-silane concentration, and the peak disappeared completely after furanone application followed by UV irradiation. As a complementary technique to XPS, TOF-SIMS provided valuable information on the chemical and molecular structure of the modified surfaces and spatial distribution of the immobilized furanone molecules. Finally, this report presents a convenient, reproducible, and robust strategy to design antibacterial coating based on furanone compounds for applications in human health care.
Tags
PFAS
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFPeA (2706-90-3)
Literature Search
Pubmed
WOS
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
(Heptafluoropropyl)trimethylsilane
Perfluoropropanoic acid
•
PFPeA
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
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