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HERO ID
3860594
Reference Type
Journal Article
Title
Direct photo-patterning of hyaluronic acid baits onto a fouling-release perfluoropolyether surface for selective cancer cell capture and immobilization
Author(s)
Credi, C; De Marco, C; Molena, E; Nava, MM; Raimondi, MT; Levi, M; Turri, S
Year
2016
Is Peer Reviewed?
1
Journal
Materials Science and Engineering C: Materials for Biological Applications
ISSN:
0928-4931
EISSN:
1873-0191
Publisher
ELSEVIER SCIENCE BV
Location
AMSTERDAM
Volume
62
Page Numbers
414-422
Language
English
PMID
26952441
DOI
10.1016/j.msec.2015.12.063
Web of Science Id
WOS:000372759100051
Abstract
A simple photolithographic process for directly patterning glycidyl methacrylate modified hyaluronic acid features onto UV curable perfluoropolyether-based surfaces is presented. Due to the versatility of the developed method, HA spotted areas with different geometrical features could be rapidly and inexpensively designed. In addition, the excellent antifouling and fouling-release properties of the substrates enabled direct HA baits photo-grafting onto PFPEs without further surface passivation or chemical modification to avoid not specific adsorption. The aim of the study was to locally switch the surface properties of the PFPEs from cells and protein repulsive to adherent. Particularly, we exploited HA well-known preferential interactions with CD44 transmembrane receptors to selectively immobilize cancer cells. Living cell arrays offer a higher-resolution visualization of HA-CD44 interactions and may provide a deep insight into understanding molecular mechanisms needed to develop selective therapies and diagnosis against tumor growth.
Keywords
UV-curing; Photolithography; Hyaluronic acid; Perfluoropolyether; Antifouling; Cancer cells; Immobilization
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
PubMed
Web of Science
Not prioritized for screening
Perfluoropentanesulfonic acid
•
Expanded PFAS SEM (formerly PFAS 430)
Perfluoropentanesulfonate
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFPeS (2706-91-4)
Literature Search
Pubmed
WOS
•
PFPeS
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
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