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HERO ID
3864295
Reference Type
Journal Article
Title
Association between air pollution and mammographic breast density in the Breast Cancer Surveilance Consortium
Author(s)
Yaghjyan, L; Arao, R; Brokamp, C; O'Meara, ES; Sprague, BL; Ghita, G; Ryan, P
Year
2017
Is Peer Reviewed?
Yes
Journal
Breast Cancer Research
ISSN:
1465-5411
EISSN:
1465-542X
Volume
19
Issue
1
Page Numbers
36
Language
English
PMID
28381271
DOI
10.1186/s13058-017-0828-3
Web of Science Id
WOS:000410569800001
URL
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-017-0828-3
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Abstract
BACKGROUND:
Mammographic breast density is a well-established strong risk factor for breast cancer. The environmental contributors to geographic variation in breast density in urban and rural areas are poorly understood. We examined the association between breast density and exposure to ambient air pollutants (particulate matter <2.5 μm in diameter (PM2.5) and ozone (O3)) in a large population-based screening registry.
METHODS:
Participants included women undergoing mammography screening at imaging facilities within the Breast Cancer Surveillance Consortium (2001-2009). We included women aged ≥40 years with known residential zip codes before the index mammogram (n = 279,967). Breast density was assessed using the American College of Radiology's Breast Imaging-Reporting and Data System (BI-RADS) four-category breast density classification. PM2.5 and O3 estimates for grids across the USA (2001-2008) were obtained from the US Environmental Protection Agency Hierarchical Bayesian Model (HBM). For the majority of women (94%), these estimates were available for the year preceding the mammogram date. Association between exposure to air pollutants and density was estimated using polytomous logistic regression, adjusting for potential confounders.
RESULTS:
Women with extremely dense breasts had higher mean PM2.5 and lower O3 exposures than women with fatty breasts (8.97 vs. 8.66 ug/m(3) and 33.70 vs. 35.82 parts per billion (ppb), respectively). In regression analysis, women with heterogeneously dense vs. scattered fibroglandular breasts were more likely to have higher exposure to PM2.5 (fourth vs. first quartile odds ratio (OR) = 1.19, 95% confidence interval (CI) 1.16 - 1.23). Women with extremely dense vs. scattered fibroglandular breasts were less likely to have higher levels of ozone exposure (fourth vs. first quartile OR = 0.80, 95% CI 0.73-0.87).
CONCLUSION:
Exposure to PM2.5 and O3 may in part explain geographical variation in mammographic density. Further studies are warranted to determine the causal nature of these associations.
Tags
NAAQS
•
ISA-Ozone (2020 Final Project Page)
Literature Search Results
Literature Search - Included
Keyword Search
Topic Classified Epidemiology
Title-Abstract Screening (SWIFT-AS) - Included
Title-Abstract Screening (SWIFT-AS) - Included
Full-Text Screening Included
Full-Text Screening Included
Included in ISA First Draft
Appendix 7
Included in ISA Final Draft
Appendix 7
•
ISA-PM (2019)
In Scope
PM Cancer-Genotox
•
LitSearch-NOx (2024)
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Cancer
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