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HERO ID
39363
Reference Type
Journal Article
Title
Ozone inhibition of tissue cholinesterase in guinea pigs
Author(s)
Gordon, T; Taylor, BF; Amdur, MO
Year
1981
Is Peer Reviewed?
1
Journal
Archives of Environmental Health
ISSN:
0003-9896
EISSN:
2331-4303
Volume
36
Issue
6
Page Numbers
284-288
Language
English
PMID
7316565
DOI
10.1080/00039896.1981.10667639
Web of Science Id
WOS:A1981MX23700002
Abstract
This study sought to determine if ozone at levels known to induce bronchial hyperreactivity in guinea pigs would inhibit tissue cholinesterase activity. Male, Hartley guinea pigs were exposed to filtered air, 0.1 ppm ozone, or 0.8 ppm ozone for 1 hr. Two hours after exposure, brain, lung, and diaphragm tissue samples were frozen for assay of cholinesterase activity. Brain cholinesterase activity was only minimally inhibited in either ozone exposure group. Both levels of ozone significantly inhibited lung cholinesterase activity compared to control animals' activity: a 17% decrease in activity in the 0.1 ppm ozone group (P less than .05) and a 16% decrease in the 0.8 ppm ozone group (P less than .05). Ozone at 0.8 ppm also inhibited activity in the diaphragm by 14% (P less than .02). To determine the degree of involvement of cholinesterase inhibition in bronchial hyperreactivity, parathion pretreated animals were challenged with histamine and the pulmonary function changes monitored. Parathion-treated animals had a peak resistance increase of 330 +/- 104% (mean +/- SE), while the control vehicle animals' increase was 165 +/- 48%. The differences were not statistically significant, but show that cholinesterase inhibition may contribute to ozone-induced bronchial hyperreactivity.
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NAAQS
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ISA-PM (2019)
•
ISA-SOx
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