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HERO ID
3964500
Reference Type
Journal Article
Title
Autoimmune thyroid disease in Indian children with type 1 diabetes mellitus
Author(s)
Menon, PSN; Vaidyanathan, B; Kaur, M
Year
2001
Is Peer Reviewed?
1
Journal
Journal of Pediatric Endocrinology & Metabolism
ISSN:
0334-018X
EISSN:
2191-0251
Volume
14
Issue
3
Page Numbers
279-286
Language
English
PMID
11308045
DOI
10.1515/jpem.2001.14.3.279
Web of Science Id
WOS:000167485000005
Abstract
The objective of the present study was to determine the prevalence of autoimmune thyroid disease in Indian children with type 1 diabetes mellitus by the assay of antibodies to thyroid peroxidase and thyroglobulin. The study population consisted of 35 children with type 1 diabetes mellitus and 32 healthy age- and sex-matched control children. Thyroid peroxidase antibodies (TPO) were determined by ELISA and thyroglobulin antibodies (TGA) by passive hemagglutination. Thyroid function tests and tests of glycemic control were also performed. These assays were repeated after six months and one year. TPO were observed in 19 (54.3%) patients compared to three (10%) controls, and TGA in 11 (31.4%) patients and none of the controls, Both these observations were statistically significant with p=0.0002 for TPO and 0.0016 for TGA, The prevalence of these antibodies was not different in boys and girls and did not change with the duration of diabetes. All patients who were positive for TGA were also positive for TPO. Thyroid function tests were abnormal in one patient who was found to have Hashimoto's thyroiditis. There is a definite need to screen all diabetic children for thyroid antibodies and carefully follow up those patients in whom these antibodies are positive.
Keywords
antithyroid antibodies; autoimmune thyroid disease; Hashimoto's thyroiditis; thyroid; thyroid peroxidase antibody; thyroglobulin antibody; type 1 diabetes mellitus
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