Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has multiple attached files:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
3981302
Reference Type
Journal Article
Title
First report on the occurrence and bioaccumulation of hexafluoropropylene oxide trimer acid: An emerging concern
Author(s)
Pan, Y; Zhang, H; Cui, Q; Sheng, N; Yeung, LWY; Guo, Y; Sun, Y; Dai, J
Year
2017
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Volume
51
Issue
17
Page Numbers
9553-9560
Language
English
PMID
28780851
DOI
10.1021/acs.est.7b02259
Web of Science Id
WOS:000410255800015
Relationship(s)
is supplemented by
11374300
: Supporting information
Abstract
Here, we report on the occurrence of a novel perfluoroalkyl ether carboxylic acid, ammonium perfluoro-2-[(propoxy)propoxy]-1-propanoate (HFPO-TA), in surface water and common carp (Cyprinus carpio) collected from the Xiaoqing River and in residents residing near a fluoropolymer production plant in Huantai County, China. Compared with the levels upstream of the Xiaoqing River, HFPO-TA concentrations (5200-68500 ng/L) were approximately 120-1600-times higher downstream after receiving fluoropolymer plant effluent from a tributary. The riverine discharge of HFPO-TA was estimated to be 4.6 t/yr, accounting for 22% of total PFAS discharge. In the wild common carp collected downstream from the point source, HFPO-TA was detected in the blood (median: 1510 ng/mL), liver (587 ng/g ww), and muscle (118 ng/g ww). The log BCFblood of HFPO-TA (2.18) was significantly higher than that of PFOA (1.93). Detectable levels of HFPO-TA were also found in the sera of residents (median: 2.93 ng/mL). This is the first report on the environmental occurrence and bioaccumulation of this novel chemical. Our results indicate an emerging usage of HFPO-TA in the fluoropolymer manufacturing industry and raise concerns about the toxicity and potential health risks of HFPO-TA to aquatic organisms and humans.
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
GenX Chemicals (CASRN 13252-13-6 and CASRN 62037-80-3)
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
Pubmed
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Perfluorinated compounds
Perfluoro-2,5-dimethyl-3,6-dioxanonanoic acid
Perfluorooctanoic acid
•
PFNA
Litsearch Update 2017-2018
PFAS Untag
Literature Search
Toxline
PFNA May 2019 Update
Toxnet
Title and Abstract Screening
Excluded
Not relevant to PECO
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search – Adverse outcome pathway (2015-present)
Pubmed
Screening Results
Excluded/Not on Topic
Literature Search Update (2013-2019)
PubMed
WOS
•
Yale PFAS Liver study
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity