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HERO ID
3993884
Reference Type
Journal Article
Title
JP8 exposure and neurocognitive performance among US Air Force personnel
Author(s)
Heaton, KJ; Maule, AL; Smith, KW; Rodrigues, EG; Mcclean, MD; Proctor, SP
Year
2017
Is Peer Reviewed?
1
Journal
NeuroToxicology
ISSN:
0161-813X
EISSN:
1872-9711
Volume
62
Page Numbers
170-180
Language
English
PMID
28687449
DOI
10.1016/j.neuro.2017.07.001
Web of Science Id
WOS:000412790800022
URL
http://
://WOS:000412790800022
Exit
Relationship(s)
has erratum
10454428
Corrigendum to '' [Neurotoxicology 62 (2017) 170–180]
Abstract
Petroleum-based fuels such as jet propellant (JP) 4, JP5, JP8, and jet A1 (JetA) are among the most common occupational chemical exposures encountered by military and civilian workforces. Although acute toxicity following high-level exposures to JP8 and similar chemical mixtures has been reported, the relationship between persistent low-level occupational exposures to jet fuels and both acute and longer-term central nervous system (CNS) function has been comparatively less well characterized. This paper describes results of neurocognitive assessments acquired repeatedly across a work week study design (Friday to Friday) as part of the Occupational JP8 Exposure Neuroepidemiology Study (OJENES) involving U.S. Air Force (AF) personnel with varying levels of exposure to jet fuel (JP8). JP8 exposure levels were quantified using both personal air monitoring and urinary biomarkers of exposure. Neurocognitive performance was evaluated using an objective, standardized battery of tests. No significant associations with neurocognitive performances were observed between individuals having regular contact and those with minimal/no direct contact with JP8 (measured by average work week levels of personal breathing zone exposure). Also, no significant findings were noted between repeated measures of absorbed dose (multi-day pre-shift urinary 1- and 2-naphthol) and reduced proficiency on neurocognitive tasks across the work week. Results suggest that occupational exposure to lower (than regulated standards) levels of JP8 do not appear to be associated with acute, measurable differences or changes in neurocognitive performance.
Tags
IRIS
•
Naphthalene
Database Searches
PubMed
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Inhalation Exposure
Epidemiological
Acute toxicity studies
October 2017 Update
PubMed
Toxline
References provided during public comment
DoD
Other
•
Naphthalene (2021 Evidence mapping publication)
Database Searches
PubMed
Toxline
Combined data set
Data set for title/abstract screening
Data set for full text review
Human studies, included
Acute toxicity studies
October 2017 Update
PubMed
Toxline
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