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4075193 
Journal Article 
SYNTHESIS AND REACTIVITY OF SOME 1,2,4-TRIAZOLO[4,3-B]PYRIDAZINE DERIVATIVES 
Baloniak, S; Katrusiak, A 
1994 
1 
Polish Journal of Chemistry
ISSN: 0137-5083 
68 
4 
683-691 
WOS:A1994NE92200005 
The triazolo[4,3-b]pyridazine derivatives were obtained in the reaction of 3-chloro-6-hydrazinopyridazine with acetic acid and ethyl chloroformate. Acting on 6-chloro-3-methyl-1,2,4-triazolo[4,3-b]pyridazine with phosphorus pentachloride, a methyl group in position 3 has unexpectedly been exchanged by chlorine. The mechanism of fusing the triazole ring to the pyridazine system has been studied by the reaction of 3-chloro-6-hydrazinopyridazine with formaldehyde, acetaldehyde, and treatment the resulting Schiff bases by bromine in acetic acid with sodium acetate added. 
1,2,4-TRIAZOLO[4,3-B]PYRIDAZINES; NUCLEOPHILIC SUBSTITUTION; CYCLIZATION MECHANISM