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Citation
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HERO ID
4146480
Reference Type
Journal Article
Title
Percutaneous toxicity of ethylene glycol monomethyl ether and of dipropylene glycol monomethyl ether in the rat
Author(s)
Fairhurst, S; Knight, R; Marrs, TC; Scawin, JW; Spurlock, MS; Swanston, DW
Year
1989
Is Peer Reviewed?
1
Journal
Toxicology
ISSN:
0300-483X
EISSN:
1879-3185
Volume
57
Issue
2
Page Numbers
209-215
Language
English
PMID
2749747
DOI
10.1016/0300-483X(89)90166-2
Web of Science Id
WOS:A1989AG18900006
Abstract
The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused changes in the haematology and clinical chemistry, and both testicular and bone marrow damage at doses of 1000 mg/kg per day.
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Glycols
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Propylene glycol ethers (88917-22-0 & 55934-93-5)
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