Oxidation of beta-blocking agents: V. Light-influenced oxidation of propranolol and its glycol with N-bromosuccinimide | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

4194665

Reference Type

Journal Article

Title

Oxidation of beta-blocking agents: V. Light-influenced oxidation of propranolol and its glycol with N-bromosuccinimide

Author(s)

Salomies, H

Year

1987

Is Peer Reviewed?

Journal

Acta Pharmaceutica Suecica
ISSN: 0001-6675

Report Number

BIOSIS/88/10436

Volume

Issue

Page Numbers

193-198

Language

English

Abstract

BIOSIS COPYRIGHT: BIOL ABS. Propranolol and one of its metabolites, propranolol glycol, were oxidized with N-bromosuccinimide in acidic and neutral solutions under irradiation from a mercury lamp. Mercuric acetate was used to prevent the bromination of the products. After an oxidation of one hour the products were isolated by extraction, preparative TLC and flash chromatography. The main products, identified by spectrometric methods, were 1,4-naphthoquinone, 2,3-dibromo-1,4-naphthoquinone and 2,4-dibromo-1-naphthol. 8-Bromo-2-hydroxy- and 2-bromo-1,4-naphthoquinone were isolated in traces.