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42064 
Technical Report 
Toxicology and carcinogenesis studies of acetonitrile (CAS No 75-05-8) in F344/N rats and B6C3F1 mice (inhalation studies) 
National Toxicology Program :: NTP 
1996 
National Toxicology Program 
Research Triangle Park, NC 
Toxicology and carcinogenicity studies were conducted by administration of acetonitrile by inhalation to groups of 56 F344/N rats of each sex at doses of 0, 100, 200, or 400 ppm (equivalent to 0, 168, 335 or 670 mg/m3) and 60 B6C3F1 mice of each sex were exposed at doses of 0, 50, 100, or 200 ppm (equivalent to 0, 84, 168, or 335 mg/m3) for 6 hours per day, 5 days per week for 2 years. Under the conditions of these 2-year inhalation studies, there was equivocal evidence of carcinogenic activity of acetonitrile in male F344/N rats based on marginally increased incidences of hepatocellular adenoma and carcinoma. There was no evidence of carcinogenic activity of acetonitrile in female F344/N rats exposed to 100, 200, or 400 ppm. There was no evidence of carcinogenic activity of acetonitrile in male or female B6C3F1 mice exposed to 50, 100, or 200 ppm. Exposure to acetonitrile by inhalation resulted increased incidences in hepatic basophilic foci in male rats and of aquamous hyperplasia of the forestomach in male and female mice.