Toxicology and carcinogenesis studies of chloroprene (CAS No 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies) | Health & Environmental Research Online (HERO)

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HERO ID

42076

Reference Type

Technical Report

Title

Toxicology and carcinogenesis studies of chloroprene (CAS No 126-99-8) in F344/N rats and B6C3F1 mice (inhalation studies)

Author(s)

National Toxicology Program :: NTP

Year

1998

Is Peer Reviewed?

Journal

National Toxicology Program Technical Report Series
ISSN: 0888-8051

Report Number

NTP TR 467; NIH PUB 98-3957

Volume

467

Page Numbers

1-379

Language

English

PMID

12579206

Abstract

Chloroprene is used almost exclusively in the manufacture of neoprene (polychloroprene). Chloroprene was chosen for study because it is a high-volume production chemical with limited information on its carcinogenic potential and because it is the 2-chloro analogue of 1,3-butadiene, a potent, multi-species, multi-organ carcinogen. Male and female F344/N rats and B6C3F mice were exposed to chloroprene 1 (greater than 96% pure) by inhalation for 16 days, 13 weeks, or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, Drosophila melanogaster, and B6C3F1 mice (bone marrow cells and peripheral blood erythrocytes).