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Tags
HERO ID
4217244
Reference Type
Journal Article
Title
Prenatal exposure to persistent organic pollutants and child overweight/obesity at 5-year follow-up: a prospective cohort study
Author(s)
Lauritzen, HB; Larose, TL; Øien, T; Sandanger, TM; Odland, JØ; van de Bor, M; Jacobsen, GW
Year
2018
Is Peer Reviewed?
1
Journal
Environmental Health
EISSN:
1476-069X
Location
England
Volume
17
Issue
1
Page Numbers
9
Language
English
PMID
29347948
DOI
10.1186/s12940-017-0338-x
Web of Science Id
WOS:000422976900001
Abstract
BACKGROUND:
Prenatal exposure to persistent organic pollutants (POPs), may influence offspring weight gain. More prospective epidemiological studies are needed to compliment the growing body of evidence from animal studies.
METHODS:
Serum from 412 pregnant Norwegian and Swedish women participating in a Scandinavian prospective cohort study were collected in 1986-88, and analyses of two perfluoroalkyl substances (PFASs) and five organochlorines (OCs) were conducted. We used linear and logistic regression models with 95% confidence intervals (CIs) to evaluate the associations between maternal serum POP concentrations at 17-20 weeks of gestation and child overweight/obesity (body mass index (BMI) ≥ 85th percentile) at 5-year follow-up. Results were further stratified by country after testing for effect modification. We also assessed potential non-monotonic dose-response (NMDR) relationships.
RESULTS:
In adjusted linear models, we observed increased BMI-for-age-and-sex z-score (β = 0.18, 95% CI: 0.01-0.35), and increased triceps skinfold z-score (β = 0.15, 95% CI: 0.02-0.27) in children at 5-year follow-up per ln-unit increase in maternal serum perfluorooctane sulfonate (PFOS) concentrations. We observed increased odds for child overweight/obesity (BMI ≥ 85th percentile) for each ln-unit increase in maternal serum PFOS levels (adjusted OR: 2.04, 95% CI: 1.11-3.74), with stronger odds among Norwegian children (OR: 2.96, 95% CI: 1.42-6.15). We found similar associations between maternal serum perfluorooctanoate (PFOA) concentrations and child overweight/obesity. We found indications of NMDR relationships between PFOS and polychlorinated biphenyl (PCB) 153 and child overweight/obesity among Swedish children.
CONCLUSION:
We found positive associations between maternal serum PFAS concentrations and child overweight/obesity at 5-year follow-up, particularly among Norwegian participants. We observed some evidence for NMDR relationships among Swedish participants.
Keywords
Index Medicus; 2018)
Tags
IRIS
•
PCBs
Hazard ID: Epidemiological evidence
Litsearches
Litsearch: Aug 2017 - Aug 2018
PubMed
•
PCBs Epi Hazard ID
Health Effects
Metabolic
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
Reference list review of included studies
Screened Studies
Excluded
Exclude (TIAB)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorooctane
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Other sources
Reference list review of included studies
Not prioritized for screening
Perfluorooctane
Perfluorooctanesulfonic acid
•
PFNA
Litsearch Update 2017-2018
PFAS Untag
Toxline
Literature Search
Toxline
Title and Abstract Screening
Full Text Screening
Excluded
Not PFNA
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
WOS
•
PFOA and PFOS OW MCLG Approaches
Cited in White Papers
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