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Citation
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HERO ID
4353918
Reference Type
Technical Report
Subtype
EPA Report
Title
DuPont-24030: FRD-902: Acute dermal irritation study in rabbits
Author(s)
Carpenter, C
Year
2007
Publisher
E.I. du Pont de Nemours and Company
Location
Wilmington, Delaware
Number of Pages
20
Language
English
Abstract
FRD-902 was applied as a single 0.5-mL dermal dose to the shaved intact skin of a single New Zealand White rabbit. Since no corrosion occurred, 2 additional rabbits were treated. The test substance was applied to a 6 cm² area of skin. The application area was covered with a 2-ply gauze square which was held in place with non-irritating tape and covered with porous tape for a semi-occlusive dressing. The rabbits were exposed to the test substance for 4 hours after which the test substance was removed. Test sites were evaluated and scored by the method of Draize for signs of dermal irritation approximately 60 minutes, and 24, 48/50, and 72 hours after test substance removal. The rabbit that was initially treated was also examined immediately after test substance removal.
Erythema (score of 1 or 2) but no edema was observed in the 3 rabbits on the day of dosing. No dermal irritation was observed at 24, 48/50, or 72 hours after removal of the test substance. No clinical signs were observed, and no body weight loss occurred.
Under the conditions of this study, FRD-902 produced erythema, which cleared by 24 hours, when applied to the skin of rabbits.
In accordance with the provisions of Directive 67/548/EEC, classification is not required based on the results of this study.
Tags
PFAS
•
GenX Chemicals (CASRN 13252-13-6 and CASRN 62037-80-3)
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