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HERO ID
4353922
Reference Type
Technical Report
Subtype
EPA Report
Title
DuPont-24114: FRD-902: Acute eye irritation study in rabbits
Author(s)
Carpenter, C
Year
2007
Publisher
E.I. du Pont de Nemours and Company
Location
Wilmington, Delaware
Number of Pages
19
Language
English
Abstract
FRD-902 was evaluated for acute eye irritation potential in 1 young adult New Zealand White rabbit. A skin irritation study was previously conducted. The test substance was not a severe skin irritant or corrosive to the skin.
An aliquot of 0.1 mL of test substance was administered to 1 eye of the animal. The treated and control eye remained unwashed following treatment. The conjunctiva, iris, and cornea of the treated eye were evaluated and scored according to a numerical scale approximately 1, 24, and 28 hours following administration of the test substance.
Brown and white discoloration of the conjunctival membrane of the treated rabbit eye, which appeared to look like necrosis, was observed at 1, 24, and 28 hours after instillation of the test substance. Corneal opacity (score of 2), iritis (score of 1), conjunctival chemosis (score of 2 or 4), and discharge (score of 2 or 3) were also observed. Fluorescein stain examinations of the treated eye were positive for corneal injury. The rabbit was euthanized the day after treatment for humane reasons.
Under the conditions of this study, FRD-902 produced ocular effects in a rabbit which appeared to look like necrosis.
Tags
PFAS
•
GenX Chemicals (CASRN 13252-13-6 and CASRN 62037-80-3)
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