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Citation
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HERO ID
4353926
Reference Type
Technical Report
Subtype
EPA Report
Title
DuPont-24126: FRD-902: Acute oral toxicity study in mice – up-and-down procedure
Author(s)
Carpenter, C
Year
2007
Publisher
E.I. du Pont de Nemours and Company
Location
Wilmington, Delaware
Number of Pages
31
Language
English
Abstract
A single dose of FRD-902 was administered by oral gavage to 1 fasted female mouse at a dose of 175 mg/kg, to 3 fasted female mice at a dose of 550 mg/kg, and to 3 fasted female mice at a dose of 1750 mg/kg. The mice were dosed one at a time at a minimum of 48-hour intervals. The mice were observed for mortality, body weight effects, and clinical signs for up to 14 days after dosing. All mice were necropsied to detect grossly observable evidence of organ or tissue damage.
Death occurred in all 3 mice dosed at 1750 mg/kg. No clinical signs were observed in the mouse dosed at 175 mg/kg or in 2 mice dosed at 550 mg/kg. Wet fur was observed on the day of dosing in 1 mouse dosed at 550 mg/kg. One mouse dosed at 1750 mg/kg was found dead on the day of dosing. No clinical signs were observed in this mouse. Another mouse dosed at 1750 mg/kg exhibited lethargy and low posture and was found dead on the day of dosing. The remaining mouse dosed at 1750 mg/kg exhibited lethargy on the day of dosing and was found dead on the day after dosing. No body weight losses occurred in surviving mice after dosing. No test substance-related gross lesions were found in the study.
Under the conditions of this study, the estimated oral LD50 for FRD-902 was 1030 mg/kg for female mice.
In accordance with the provisions of Directive 67/548/EEC, classification is required based on the results of this study. FRD-902 is classified as harmful and assigned the symbol “Xn” and the risk phrase R22 Harmful if swallowed.
Tags
PFAS
•
GenX Chemicals (CASRN 13252-13-6 and CASRN 62037-80-3)
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