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Tags
HERO ID
4238499
Reference Type
Journal Article
Title
Perfluorohexadecanoic acid increases paracellular permeability in endothelial cells through the activation of plasma kallikrein-kinin system
Author(s)
Liu, QS; Hao, F; Sun, Z; Long, Y; Zhou, Q; Jiang, G
Year
2018
Is Peer Reviewed?
Yes
Journal
Chemosphere
ISSN:
0045-6535
EISSN:
1879-1298
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Location
OXFORD
Volume
190
Page Numbers
191-200
Language
English
PMID
28987408
DOI
10.1016/j.chemosphere.2017.10.002
Web of Science Id
WOS:000414881600021
URL
https://linkinghub.elsevier.com/retrieve/pii/S0045653517315758
Exit
Relationship(s)
is supplemented by
4442170
: Supplementary materials
Abstract
Per- and polyfluoroalkyl substances (PFASs) are ubiquitous and high persistent in human blood, thus potentially inducing a myriad of deleterious consequences. Plasma kallikrein-kinin system (KKS), which physiologically regulates vascular permeability, is vulnerable to exogenous stimulators, like PFASs with long-chain alkyl backbone substituted by electronegative fluorine. The study on the interactions of PFASs with the KKS and the subsequent effects on vascular permeability would be helpful to illustrate how the chemicals penetrate the biological vascular barriers to reach different tissues. In present study, three representative PFASs, including perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA) and perfluorohexadecanoic acid (PFHxDA), were investigated for their effects on the activation of the KKS, paracellular permeability in human retina endothelial cells (HRECs) and integrity of the adherens junctions. In contrast to either PFOS or PFOA, PFHxDA efficiently triggered KKS activation in a concentration-dependent manner based on protease activity assays. The plasma activated by PFHxDA significantly increased paracellular permeability of HRECs through the degradation of adherens junctions. As evidenced by the antagonistic effect of aprotinin, PFHxDA-involved effects on vascular permeability were mediated by KKS activation. The results herein firstly revealed the mechanistic pathway for PFHxDA induced effects on vascular endothelial cells. Regarding the possible structure-related activities of the chemicals, this finding would be of great help in the risk assessment of PFASs.
Keywords
Per- and polyfluoroalkyl substances; Kallikrein-kinin system; Endothelial cells; Paracellular permeability; Adherens junctions; Vascular endothelial cadherin
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorooctane
Potassium perfluorooctanoate
Sodium perfluorooctanoate
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Ammonium perfluorooctanoate
Perfluorinated compounds
Perfluorooctane
Perfluorooctanesulfonic acid
Perfluorooctanoic acid
•
PFHxS
•
PFNA
Litsearch Update 2017-2018
PFAS Untag
Literature Search
Toxline
PFNA May 2019 Update
Toxnet
Title and Abstract Screening
Full Text Screening
Excluded
Not PFNA
Studies Meeting PECO
Human health effects studies
Tagged as Supplemental
Mechanistic or MOA
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
PubMed
WOS
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