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HERO ID
4239569
Reference Type
Journal Article
Title
Sex-specific risk assessment of PFHxS using a physiologically based pharmacokinetic model
Author(s)
Kim, SJ; Shin, H; Lee, YB; Cho, HY
Year
2018
Is Peer Reviewed?
Yes
Journal
Archives of Toxicology
ISSN:
0340-5761
EISSN:
1432-0738
Publisher
SPRINGER HEIDELBERG
Location
HEIDELBERG
Volume
92
Issue
3
Page Numbers
1113-1131
Language
English
PMID
29143853
DOI
10.1007/s00204-017-2116-5
Web of Science Id
WOS:000428320800009
URL
https://search.proquest.com/docview/1965248930?accountid=171501
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Abstract
Perfluorohexanesulfonate (PFHxS), which belongs to the group of perfluoroalkyl and polyfluoroalkyl substances (PFASs), has been extensively used in industry and subsequently detected in the environment. Its use may be problematic, as PFHxS is known to induce neuronal cell death, and has been associated with early onset menopause in women and with attention deficit/hyperactivity disorder. Due to these impending issues, the aim of this study is to develop and evaluate a physiologically based pharmacokinetic (PBPK) model for PFHxS in male and female rats, and apply this to a human health risk assessment. We conducted this study in vivo after the oral or intravenous administration of PFHxS in male (dose of 10 mg/kg) and female rats (dose of 0.5-10 mg/kg). The biological samples consisted of plasma, nine tissues, urine, and feces. We analyzed the sample using ultra-liquid chromatography coupled tandem mass spectrometry (UPLC-MS/MS). Our findings showed the tissue-plasma partition coefficients for PFHxS were highest in the liver. The predicted rat plasma and tissue concentrations using a simulation fitted well with the observed values. We extrapolated the PBPK model in male and female rats to a human PBPK model of PFHxS based on human physiological parameters. The reference doses of 0.711 µg/kg/day (male) and 0.159 µg/kg/day (female) and external doses of 0.007 µg/kg/day (male) and 0.006 µg/kg/day (female) for human risk assessment were estimated using Korean biomonitoring values. This study provides valuable insight into human health risk assessment regarding PFHxS exposure.
Keywords
PBPK; Perfluorohexanesulfonate (PFHxS); Human health risk assessment; Rat
Tags
PFAS
•
Additional PFAS (formerly XAgency)
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorinated compounds
Perfluorohexanesulfonic acid
Perfluorooctanoic acid
•
PFBA
Protocol References
•
PFHxS
Database searches
Pubmed
Toxline
Scopus
Inclusion
TiAb
Full Text
PBPK or PK model
Supplemental
Full Text
ADME/toxicokinetic (excluding models)
•
PFNA
Litsearch Update 2017-2018
PFAS Untag
Toxline
Literature Search
Toxline
Title and Abstract Screening
Full Text Screening
Excluded
Not PFNA
Tagged as Supplemental
ADME
•
PFOA (335-67-1) and PFOS (1763-23-1)
Literature Search Update (2013-2019)
WOS
•
Yale PFAS Liver study
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