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4239831 
Journal Article 
Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles 
Prandina, A; Herfindal, L; Radix, S; Rongved, P; Døskeland, SO; Le Borgne, M; Perret, F 
2018 
Yes 
Journal of Enzyme Inhibition and Medicinal Chemistry
ISSN: 1475-6366
EISSN: 1475-6374 
33 
1 
370-375 
English 
29336193 
Phenazine is known to regroup planar nitrogen-containing heterocyclic compounds. It was used here to enhance the bioavailability of the biologically important compound iodinin, which is near insoluble in aqueous solutions. Its water solubility has led to the development of new formulations using diverse amphiphilic α-cyclodextrins (CDs). With the per-[6-desoxy-6-(3-perfluorohexylpropanethio)-2,3-di-O-methyl]-α-CD, we succeeded to get iodinin-loaded nanoformulations with good parameters such as a size of 97.9 nm, 62% encapsulation efficiency and efficient control release. The study presents an interesting alternative to optimizing the water solubility of iodinin by chemical modifications of iodinin. 
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