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HERO ID
4239873
Reference Type
Journal Article
Title
A novel local drug delivery system: Superhydrophobic titanium oxide nanotube arrays serve as the drug reservoir and ultrasonication functions as the drug release trigger
Author(s)
Zhou, J; Frank, MA; Yang, Y; Boccaccini, AR; Virtanen, S
Year
2018
Is Peer Reviewed?
1
Journal
Materials Science and Engineering C: Materials for Biological Applications
ISSN:
0928-4931
EISSN:
1873-0191
Volume
82
Page Numbers
277-283
Language
English
PMID
29025658
DOI
10.1016/j.msec.2017.08.066
Abstract
A local drug delivery system consisting of superhydrophobic titanium oxide nanotube (S-TNTs) arrays and ultrasonic-controlled release trigger was developed in this work. Hydrophilic TNTs arrays are converted into superhydrophobic after being treated by 1H,1H,2H,2H- perfluorooctyl-triethoxysilane (POTS). S-TNTs arrays serving as a drug-carrying vehicle require no extra sealing treatment due to the excellent isolation effect from the trapped air layer on the surface. Different amounts of drugs could be loaded into S-TNTs arrays by control of the structure of arrays (including length and diameter of tubes) and the original amount of drug in the drug-loading solution. The relation between surface morphology of TNTs arrays and superhydrophobicity (isolation effect) was thoroughly investigated. To achieve a stimulus-responsive drug delivery system, ultrasonication was employed as an efficient drug release trigger. Trapped air layer could be selectively removed by ultrasonication, and therefore the loaded drug could be released in a multiple and controlled manner. Any drugs that can dissolve in nonpolar solutions are expected to be suitable for this local drug delivery system.
Keywords
Drug release; External stimulation; Release trigger; Superhydrophobic; Titanium nanotube arrays; Ultrasonication
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