US EPA

4240348 

Journal Article 

Tumorigenesis by N-n-propyl-N-formylhydrazine in mice 

Toth, B; Nagel, D; Patil, K 

1980 

Yes 

British Journal of Cancer
ISSN: 0007-0920
EISSN: 1532-1827 

HEEP/81/09934 

42 

6 

922-928 

English 

7459225 

HEEP COPYRIGHT: BIOL ABS. Continuous administration of 0.04% N-n-propyl-N-formylhydrazine (PFH) for life in drinking water to 6 wk old randomly bred Swiss mice induced tumors of the lungs, preputial glands, liver and gall bladder. The tumor incidences in these 4 tissues were 91, 22, 8 and 6%; in the untreated controls they were 25, 0, 0.5 and 0.5%, respectively. The higher dose of 0.08% PFH, given under identical conditions, induced only tumors of the lungs, liver and gall bladder in lower incidences, since the compound was too toxic for the mice. Histopathologically, the tumors were classified as adenomas and adenocarcinomas of the lungs, squamous cell papillomas, carcinomas and fibrosarcoma of preputial glands, benign hepatomas, liver cell carcinoma and adenomas and adenocarcinoma of the gall bladder. The investigation is part of a structure/activity relationship inquiry aimed at revealing the mechanism of action of the N-alkyl-N-formylhydrazine series of chemicals.