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Citation
Tags
HERO ID
4289872
Reference Type
Journal Article
Subtype
Review
Title
Developmental exposures to perfluoroalkyl substances (PFASs): An update of associated health outcomes
Author(s)
Liew, Z; Goudarzi, H; Oulhote, Y
Year
2018
Is Peer Reviewed?
1
Journal
Current Environmental Health Reports
EISSN:
2196-5412
Volume
5
Issue
1
Page Numbers
1-19
Language
English
PMID
29556975
DOI
10.1007/s40572-018-0173-4
Web of Science Id
WOS:000544898600001
URL
http://link.springer.com/10.1007/s40572-018-0173-4
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Abstract
PURPOSE OF REVIEW:
We reviewed and summarized the epidemiological evidence for the influence that pre- and postnatal exposures to perfluoroalkyl substances (PFASs) may have on health outcomes in offspring, with a particular focus on birth outcomes and postnatal growth, immunomodulatory effects and neurodevelopment.
RECENT FINDINGS:
PFASs are persistent organic pollutants that have been widely produced and used in a range of commercial products since the 1950s. Human exposures to PFASs are nearly ubiquitous globally, but studies that addressed potential health effects of PFASs have only begun to accumulate in recent years. Animal studies suggest adverse effects resulting from developmental encompasses prenatal exposures to PFASs. In humans, the developing fetus is exposed to PFASs via active or passive placenta transfer, while newborns might be exposed via breastfeeding or PFAS in the home environment. Overall, epidemiological findings are consistent and suggest possible associations with fetal and postnatal growth and immune function, while the findings on neurodevelopmental endpoints to date are rather inconclusive. Methodological challenges and future directions for PFASs-focused research are discussed
Keywords
Developmental exposures; Fetal growth; Immunotoxicity; Neurodevelopment; Perfluoroalkyl substances
Tags
PFAS
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Other Sources
Reference list review of included studies
Screened Studies
Supplemental
•
PFAS 150
Literature Search August 2019
Other sources
Reference list review of included studies
Screened Studies
Supplemental
•
PFBS
•
PFHxS
•
PFNA
Literature Search
Toxline
PFNA May 2019 Update
Toxnet
Title and Abstract Screening
Tagged as Supplemental
Other PFAS
Other
•
PFOA (335-67-1) and PFOS (1763-23-1)
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